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Attempts to isolate a kallikrein inhibitor from rat salivary gland

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Abstract

Besides the oxytocic principle (kallikrein) it was possible to separate from the rat submandibular gland extract an inhibitor presenting a specific antagonism against the oxytocic action of the submandibular gland kallikrein.

A protein fraction collected from sephadex G-100 column showed maximal oxytocic activity, with an OD at about 500 and an inhibitory effect with an OD at about 1700, indicated by absorption at 280 mμ.

Since the inhibitor appears in fractions following those holding the kallikrein activity, it is suggested that it has a lower molecular size than kallikrein.

The concentration of the inhibitor in the gland increases parallel with the development of animal.

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References

  1. R. L. Araujo, W. Dias da Silva andW. T. Beraldo,Kininogenic and Oxytocic Properties of Rat Pancreatic Juice, in;Bradykinin and Related Kinins. Cardiovascular, Biochemical and Neural Actions, Adv. exp. Med. Biol.8, 77 (1970) (Ed. F. Sicuteri, M. Rocha e Silva and N. Back, Plenum Press).

  2. W. T. Beraldo, R. L. Araujo andM. Mares-Guia,Oxytocic Esterase in Rat Urine, Am. J. Physiol.211, 975 (1966).

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  3. W. T. Beraldo, G. Siqueira, J. A. A. Rodrigues andConceição R. S. Machado,Changes inKallikrein ACtivity of Rat Submandibullar Gland during Post-Natal Development. Vasopeptides. Chemistry, Pharmacology, and Pathophysiology, Adv. exp. Med. Biol.21, 239 (1972) (Ed. N. Back and F. Sicuteri, Plenum Press).

  4. G. Siqueira, J. A. A. Rodrigues, C. R. S. Machado andW. T. Beraldo,Kallikrein and Kallikrein-Inhibitor n Rat Submandibular Gland during Development, Fifth international Congress on Pharmacology, 23–28 July, San Francisco, USA 1972.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Institute of Biological Sciences, UFMG, Belo Horizonte, Brazil

    G. Siqueira & W. T. Beraldo

Authors
  1. G. Siqueira
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  2. W. T. Beraldo
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Siqueira, G., Beraldo, W.T. Attempts to isolate a kallikrein inhibitor from rat salivary gland. Agents and Actions 3, 323–325 (1973). https://doi.org/10.1007/BF01986488

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  • DOI: https://doi.org/10.1007/BF01986488

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