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Histamine and 5-hydroxytryptamine uptake by some mucopolysaccharides

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Abstract

Various experiments in vitro (dialysis equilibrium, pharmacological action on the guinea-pig ileum, chromatography in Sephadex columns) and in vivo (studies on the bronchospasm of the guinea-pig) lead to the conclusion of a fixation of histamine by the sulfuric ester of pentosan. The activity of this product on the bronchospasm by serotonin has also been demonstrated. The biochemical properties of this substance lead to a decrease of the pharmacologic alactivity of histamine and serotonin, known to be involved in inflammatory reactions.

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Authors and Affiliations

  1. Département de Physiologie, Faculté de Médecine Necker-Enfants-Malades, 156, rue de Vaugirard, Paris, France

    Jean-Louis Parrot, Madeleine Mordelet-Dambrine & Paulette Canu

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  1. Jean-Louis Parrot
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  2. Madeleine Mordelet-Dambrine
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  3. Paulette Canu
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Parrot, JL., Mordelet-Dambrine, M. & Canu, P. Histamine and 5-hydroxytryptamine uptake by some mucopolysaccharides. Agents and Actions 3, 292–296 (1973). https://doi.org/10.1007/BF01986483

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  • DOI: https://doi.org/10.1007/BF01986483

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