Skip to main content
SpringerLink
Log in

The effect of diphosphonates on periosteal and bone cells in culture

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Calvaria cells were separated into periosteal and bone cells and cultured in the presence of ethane-1-hydroxyl,1-diphosphonate (EHDP) or dichloromethanediphosphonate (Cl2MDP). Both cell types were affected to the same degree with respect to the effect on cell number and lactate production. The action of the diphosphonates seems therefore not to be specific for one of the cell types.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. H. A. Fleisch, R. G. G. Russell, S. Bisaz, R. C. Mühlbauer and D. A. Williams, Eur. J. clin. Invest.1, 12 (1970).

    PubMed  Google Scholar 

  2. R. G. G. Russell, R. C. Mühlbauer, S. Bisaz, D. A. Williams and H. Fleisch Calcif. Tissue Res.6, 183 (1970).

    PubMed  Google Scholar 

  3. O. L. M. Bijvoet, A. J. G. Nollen, T. J. J. H. Slooff and R. Feith, Acta orthop. scand.45, 926 (1974).

    PubMed  Google Scholar 

  4. S. L. Stover H. R. Hahn and J. M. Miller, Paraplegia14, 146 (1976).

    PubMed  Google Scholar 

  5. R. G. G. Russell, R. Smith, C. Preston, R. J. Walton and C. G. Woods, Lancet1, 894 (1974).

    PubMed  Google Scholar 

  6. W. B. Frijlink, O. L. M. Bijvoet, J. te Velde and G. Heynen, Lancet1, 799 (1979).

    Article  PubMed  Google Scholar 

  7. P. J. Meunier, M. C. Chapuy, C. Alexandre, C. Bressot, C. Edouard, E. Vignon, L. Mathieu and U. Trechsel, Lancet2, 489 (1979).

    Article  PubMed  Google Scholar 

  8. F. J. M. van Breukelen, O. L. M. Bijvoet and A. T. van Oosterom, Lancet1, 803 (1979).

    Article  PubMed  Google Scholar 

  9. E. S. Siris, W. H. Sherman, D. C. Baquiran, J. P. Schlatterer, E. F. Osserman and R. E. Canfield, New Engl. J. Med.302, 310 (1980).

    PubMed  Google Scholar 

  10. D. K. Fast, R. Felix, C. Dowse, W. F. Neuman and H. Fleisch, Biochem. J.172, 97 (1978).

    PubMed  Google Scholar 

  11. J. J. Ende, Proc. K. ned. Akad. Wet.81C, 252 (1978).

    Google Scholar 

  12. R. Felix, D. K. Fast, J. D. Sallis and H. Fleisch, Calcif. Tissue Int.30, 163 (1980).

    PubMed  Google Scholar 

  13. R. Felix and H. Fleisch, Biochem. J.196, 237 (1981).

    PubMed  Google Scholar 

  14. R. Felix and H. Fleisch, Biochem. J.183, 73 (1979).

    PubMed  Google Scholar 

  15. H. L. Guenther, H. E. Guenther and H. Fleisch, Biochem. J.196, 293 (1981).

    PubMed  Google Scholar 

  16. H. L. Guenther, H. E. Guenther and H. Fleisch, Biochem. J.184, 203 (1979).

    PubMed  Google Scholar 

  17. R. A. Luben, G. L. Wong and D. V. Cohn, Endocrinology99, 526 (1976).

    PubMed  Google Scholar 

  18. W. A. Peck, J. K. Burks, J. Wilkins, S. B. Rodan and G. A. Rodan, Endocrinology100, 1357 (1977).

    PubMed  Google Scholar 

  19. P. C. Engel and J. B. Jones, Analyt. Biochem.88, 475 (1978).

    Article  PubMed  Google Scholar 

  20. G. Wong and D. V. Cohn, Nature252, 713 (1974).

    PubMed  Google Scholar 

  21. A. G. Gilman, Proc. natl. Acad. Sci. USA67, 305 (1970).

    PubMed  Google Scholar 

  22. S. C. Miller and W. S. S. Jee, Calcif. Tissue Res.23, 207 (1977).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathophysiology, University of Berne, Murtenstrasse 35, CH-3010, Berne, Switzerland

    R. Felix & H. Fleisch

Authors
  1. R. Felix
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Fleisch
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Acknowledgment. We thank Miss J. Portenier for her skilled technical assistance and Mrs N. Borel and B. Meier for preparing the manuscript. This work has been supported by the Swiss National Science Foundation (grant 3.824.79) by the Procter & Gamble Company, Cincinnati, USA, and by the Ausbildungs- und Förderungsfonds der Arbeitsgemeinschaft für Osteosynthese (AO), Chur, Switzerland.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Felix, R., Fleisch, H. The effect of diphosphonates on periosteal and bone cells in culture. Experientia 37, 817–819 (1981). https://doi.org/10.1007/BF01985657

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01985657

Keywords

Search

Navigation