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A new solid-phase synthesis of thymopoietin II by a mild procedure

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Summary

The solid-phase synthesis of a nonatetracontapeptide corresponding to the entire amino acid sequence of Thymopoietin II is described. Use of the recently developed, base-labile, fluorenylmethyloxycarbonyl-amino acids in combination withtert-butyl based side chain protecting groups and p-alkoxybenzyl ester peptide to resin linkage enabled the synthesis to be carried out under much milder reaction conditions than previously.

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Author notes

  1. R. Colombo

    Present address: St. Raphael Hospital Research Department, University of Milan, Via Olgettina 60, I-20132, Milan, (Italy)

Authors and Affiliations

  1. Department of Pharmacology, University of Milan, I-20129, Milan, Italy

    R. Colombo

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  1. R. Colombo
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Colombo, R. A new solid-phase synthesis of thymopoietin II by a mild procedure. Experientia 37, 798–800 (1981). https://doi.org/10.1007/BF01985646

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  • DOI: https://doi.org/10.1007/BF01985646

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