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In vivo inhibition of plasma protein leakage andSalmonella enteritidis—induced mortality in the rat by a specific paf-acether antagonist: BN 52021

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Abstract

The effects of BN 52021, a new specific paf-acether receptor antagonist and the total Ginkgo biloba extract (GBE 761) from which this product was isolated, were studied in the rat on paf-acether-induced permeability and cell number changes and on endotoxin-induced lethality.

Their activities were compared to those of cycloxygenase, 5-lipoxygenase and phospholipase A2 inhibitors. BN 52021 given s.c. or orally exerted a dose-related inhibition of paf-acether deleterious effects as well as of endotoxin lethality whereas the other drugs tested were poorly effective. These results strongly suggest paf-acether involvement in endotoxic and septic shock.

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Authors and Affiliations

  1. I.H.B.—IPSEN Institute for Therapeutic Research, 17, Avenue Descartes, F-92350, Le Plessis Robinson, (France)

    A. Etienne, F. Hecquet, C. Soulard, B. Spinnewyn, F. Clostre & P. Braquet

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  1. A. Etienne
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  2. F. Hecquet
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  3. C. Soulard
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  4. B. Spinnewyn
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  5. F. Clostre
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  6. P. Braquet
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Etienne, A., Hecquet, F., Soulard, C. et al. In vivo inhibition of plasma protein leakage andSalmonella enteritidis—induced mortality in the rat by a specific paf-acether antagonist: BN 52021. Agents and Actions 17, 368–370 (1986). https://doi.org/10.1007/BF01982649

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  • DOI: https://doi.org/10.1007/BF01982649

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