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Voltage-clamp analysis of the sodium and potassium currents in skeletal muscle fibres treated with 4-aminopyridine

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Summary

External application of low concentrations of 4-aminopyridine blocks potassium currents without affecting sodium currents in pieces of single frog skeletal muscle fibres. The blockade of potassium currents was voltage-dependent, being partially relieved on depolarization.

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Author notes

  1. J. Molgó

    Present address: Institut de Pharmacologie, Laboratoire Associé du C.N.R.S. n° 206, 21, rue de l'Ecole de Médecine, 75006, Paris, France

Authors and Affiliations

  1. Departamento de Farmacologia, Facultad de Medicina Campus Santiago Norte, Universidad de Chile, Casilla 16387, Santiago 9, Chile

    J. Molgó

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  1. J. Molgó
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Additional information

This study was supported by a grant from the Oficina técnica de Desarrollo Cientifico of the University of Chile (Project 4437-R, 1977).

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Molgó, J. Voltage-clamp analysis of the sodium and potassium currents in skeletal muscle fibres treated with 4-aminopyridine. Experientia 34, 1275–1277 (1978). https://doi.org/10.1007/BF01981414

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  • DOI: https://doi.org/10.1007/BF01981414

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