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Mechanisms of oxidant-induced changes in erythrocytes

  • Inflammation and Immunomodulation
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Abstract

There is an increasing body of experimental studies demonstrating the toxic effects of oxygen-derived free radicals. Evidence supports an important role for free radicals in ischemic injuries, inflammation, and chemical-induced tissue injury. Free radicals are involved in normal biochemical processes like oxidative reduction and cellular metabolism; however, they also mediate disease processes. The participation of oxygen free radicals in lysis of red cells is important in some situations of intravascular hemolysis. This article will review neutrophil-derived oxygen free radicals, emphasizing: (1) their effects on the erythrocyte and (2) how these effects may be attenuated.

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Authors and Affiliations

  1. Radian Corporation, 2250 E. Imperial Hwy., Suite 140, 90245, El Segundo, CA, USA

    J. R. Hatherill

  2. Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA

    G. O. Till & P. A. Ward

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  1. J. R. Hatherill
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  2. G. O. Till
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  3. P. A. Ward
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Supported in part by NIH Grants HL-31963, GM-28499, and GM-29507.

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Hatherill, J.R., Till, G.O. & Ward, P.A. Mechanisms of oxidant-induced changes in erythrocytes. Agents and Actions 32, 351–358 (1991). https://doi.org/10.1007/BF01980898

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