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Transformation of chloramphenicol palmitate from therapeutically inactive polymorph A to active polymorph B

Identification and determination of modification A in modification B by DSC

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Abstract

The bioeffectivity of the therapeutically stable modification A of chloramphenicol palmitate is essentially less than that of the metastable modification B. The literature data indicate that the transformation of modification B to modification A is always monotropic. However, by means of cyclic heat treatment, the stable, inactive modification A has now been successfully transformed to the ‘metastable’, but pharmaceutically effective modification B. For identification and determination of the inactive polymorph A (as impurity) in the active polymorph B, DSC affords rapid and well-reproducible results on small samples. This method may be recommended for inclusion in pharmacopoeias.

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Authors and Affiliations

  1. Institute of Inorganic and Analytical Chemistry, L. Eötvös University, P.O. Box 32, 1518, Budapest 112, Hungary

    Zs. Csakurda-Harmathy & I. Konkoly Thege

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  1. Zs. Csakurda-Harmathy
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  2. I. Konkoly Thege
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Csakurda-Harmathy, Z., Thege, I.K. Transformation of chloramphenicol palmitate from therapeutically inactive polymorph A to active polymorph B. Journal of Thermal Analysis 50, 867–871 (1997). https://doi.org/10.1007/BF01979216

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  • DOI: https://doi.org/10.1007/BF01979216

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