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Chronic immune synovitis in rabbits. I. Immunoglobulin andβ-glucuronidase analyses of synovial tissues and joint exudates

  • Immunosuppression and Inflammation
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Abstract

Immunoglobulin andβ-glucuronidase levels in joint exudates and homogenates of synovial tissues were measured during the course of bovine serum albumin (BSA) antigen-induced synovitis in rabbits. After intra-articular BSA challenge, the anti-BSA hemagglutinating antibody in tissue homogenates increased with time up to 14 days. Results obtained indicated relatively greater increases in specific anti-BSA activity compared with total IgG and are compatible within vivo antibody synthesis by inflamed synovial tissue.β-glucuronidase was measured as a reflection of phagocytic cell activity. Tissue enzyme levels increased to a maximum at 1 day and this level persisted up to at least 7 days, despite the fact that exudate enzyme levels reached a maximum at 1 day and then declined significantly over the next 2–3 weeks. These observations reinforce the view that inflamed synovial tissue possesses a substantial potential for perpetuating joint destruction by producing increased levels of inflammatory mediators.

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  1. Department of Experimental Pathology, Squibb Institute for Medical Research, Princeton, New Jersey, USA

    M. Barry Goldlust & Lois C. Rich

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  1. M. Barry Goldlust
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  2. Lois C. Rich
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Goldlust, M.B., Rich, L.C. Chronic immune synovitis in rabbits. I. Immunoglobulin andβ-glucuronidase analyses of synovial tissues and joint exudates. Agents and Actions 11, 723–728 (1981). https://doi.org/10.1007/BF01978796

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  • DOI: https://doi.org/10.1007/BF01978796

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