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Leukotrienes C and D induce bronchoconstriction in man

  • Proceedings of the 3rd European Workshop on Inflammation, Paris, 2–3 March 1981
  • Lipoxygenase-Derived Metabolites of Arachidonate: Release and Mode of Action
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Abstract

Pulmonary responses to aerosols of synthetic leukotrienes C and D were examined in two normal volunteers. The leukotrienes were equipotent and equieffective in producing moderate bronchoconstriction accompanied by coughing. Changes in FEV1 were slight, but changes in expiratory flow at low lung volumes were more notable. FPL 55712 abolished the cough response and partially inhibited the bronchoconstriction.

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Authors and Affiliations

  1. Pharmaceutical Division, R and D Laboratories, Fisons Ltd, Bakewell Road, LE11 0QY, Loughborough, Leicestershire, UK

    M. C. Holroyde, R. E. C. Altounyan, M. Cole, M. Dixon & E. V. Elliott

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  1. M. C. Holroyde
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  2. R. E. C. Altounyan
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  3. M. Cole
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  4. M. Dixon
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  5. E. V. Elliott
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Holroyde, M.C., Altounyan, R.E.C., Cole, M. et al. Leukotrienes C and D induce bronchoconstriction in man. Agents and Actions 11, 573–574 (1981). https://doi.org/10.1007/BF01978746

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  • DOI: https://doi.org/10.1007/BF01978746

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