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Effect of synthetic PAF-acether on human neutrophil function

  • Proceedings of the 3rd European Workshop on Inflammation, Paris, 2–3 March 1981
  • Phospholipase: Role in Cellular Activation
  • Published:
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Abstract

Synthetic PAF-acether was studied for its effect on human neutrophil migration and secretion. Based on checker-board analysis, the factor is chemokinetic for neutrophils, but it also enhances ECF-stimulated chemotaxis. By itself, PAF-acether does not induce ECF orβ-glucuronidase secretion from neutrophils, but it causes a dose-dependent enhancement of release in the presence of zymosan. PAF-acether thus potentially modulates neutrophil functions during inflammatory events.

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Authors and Affiliations

  1. Universitäts-Hautklinik, 4400, Münster, Federal Republic of Germany

    Beate M. Czarnetzki & Jacques Benveniste

  2. INSERM, U 200, Clamart/Paris, France

    Beate M. Czarnetzki & Jacques Benveniste

Authors
  1. Beate M. Czarnetzki
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  2. Jacques Benveniste
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Czarnetzki, B.M., Benveniste, J. Effect of synthetic PAF-acether on human neutrophil function. Agents and Actions 11, 549–550 (1981). https://doi.org/10.1007/BF01978734

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  • DOI: https://doi.org/10.1007/BF01978734

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