Abstract
In conventional in vitro tests and an experimental bladder model ciprofloxacin proved very active against 103 strains of enterobacteria isolated from infected urine. Nalidixic acidresistant strains were less susceptible to ciprofloxacin than nalidixic acid-sensitive strains, and the activity of the drug was reduced under acid conditions. Nevertheless, all strains were inhibited by 4 mg/l of ciprofloxacin at pH 5.5.Streptococcus spp.,Staphylococcus aureus,Pseudomonas aeruginosa andBacteroides spp. were less susceptible than enterobacteria, although most strains were inhibited by a therapeutically achievable concentration of 2 mg/l. Under conditions simulating the treatment of bacterial cystitis, changing concentrations of ciprofloxacin well within levels achievable in urine inhibited dense bacterial cultures for periods exceeding 24 hours, and surviving bacteria did not exhibit any reduction in susceptibility.
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References
Acar, J. F., Norrby, R. (ed.): Norfloxacin: microbiology, pharmacology, clinical evaluation. European Journal of Clinical Microbiology 1983, 2: 225–276.
Wise, R., Andrews, J. M., Edwards, L. J.: In vitro activity of Bay 09867, a new quinolone derivative, compared with those of other antimicrobial agents. Antimicrobial Agents and Chemotherapy 1983, 23: 559–564.
Fass, R. J.: In vitro activity of ciprofloxacin (Bay 09867). Antimicrobial Agents and Chemotherapy 1983, 24: 568–574.
Greenwood, D., O'Grady, F.: An in vitro model of the urinary bladder. Journal of Antimicrobial Chemotherapy 1978, 4: 113–120.
Greenwood, D., O'Grady, F.: Factors governing the emergence of resistance to nalidixic acid in the treatment of urinary tract infection. Antimicrobial Agents and Chemotherapy 1977, 12: 678–681.
Greenwood, D., Osman, M., Goodwin, J., Cowlishaw, W. A., Slack, R.: Norfloxacin: activity against urinary tract pathogens and factors influencing the emergence of resistance. Journal of Antimicrobial Chemotherapy 1984, 13: 315–323.
Greenwood, D., O'Grady, F.: Comparison of the responses ofEscherichia coli andProteus mirabilis to sevenβ-lactam antibiotics. Journal of Infectious Diseases 1973, 128: 211–222.
Stokes, E. J., Ridgway, G. L.: Clinical Bacteriology. 5th Edition. Edward Arnold, London, 1980, p. 209–219.
Crump, B., Wise, R., Dent, J.: Pharmacokinetics and tissue penetration of ciprofloxacin. Antimicrobial Agents and Chemotherapy 1983, 24: 784–786.
Greenwood, D., Laverick, A.: Activities of newer quinolones against legionella group organisms. Lancet 1983, ii: 279–280.
Bailey, R. R. (ed.): Single dose treatment of urinary tract infection. ADIS Health Science Press, Sydney, 1983.
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Greenwood, D., Baxter, S., Cowlishaw, A. et al. Antibacterial activity of ciprofloxacin in conventional tests and in a model of bacterial cystitis. Eur. J, Clin. Microbiol. 3, 351–354 (1984). https://doi.org/10.1007/BF01977493
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DOI: https://doi.org/10.1007/BF01977493