Skip to main content
SpringerLink
Log in

Inflammatory mechanisms in the Arthus reaction

  • Immunosuppression and Inflammation
  • Published:
Agents and Actions Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. M. Arthus,Injections repetees de serum de cheval chez le lapin, C. R. Soc. Biol.55, 817–820 (1903).

    Google Scholar 

  2. R. A. A. Coombs and P. G. H. Gell, Classification of allergic reactions responsible for clinical hypersensitivity and disease. InClinical Aspects of Immunology, pp. 761–781 (Eds. P. G. H. Gell and R. R. A. Coombs). Blackwell (1968).

  3. C. G. Cochrane,Mediators of the Arthus and related reactions, Prog. Allerg.11, 1–35 (1967).

    Google Scholar 

  4. C. V. DeShazo, P. M. Henson and C. G. Cochrane,Acute immunologic arthritis in rabbits. J. Clin. Invest.51, 50–57 (1972).

    Google Scholar 

  5. C. G. Cochrane and A. Janoff, The Arthus reaction: a model of neutrophil and complement-mediated injury. InThe inflammatory process, Vol. III, pp. 85–162 (Eds B. W. Zweifach, L. Grant and R. T. McCluskey). Academic Press, New York (1974).

    Google Scholar 

  6. K. J. Johnson and P. A. Ward,Acute immunologic pulmonary alveolitis. J. Clin. Invest.54, 349–357 (1974).

    Google Scholar 

  7. J. P. Crawford, H. Z. Movat, J. O. Minta, and M. Opas,Acute inflammation induced by immune complexes in the microcirculation. Exp. Mol. Pathol.42, 175–193 (1985).

    Google Scholar 

  8. P. J. Jose, M. J. Forrest and T. J. Williams,Detection of the complement fragment C5a in inflammatory exudates from the rabbit peritoneal cavity using radioimmunoassay, J. Exp. Med.158, 2177–2182 (1983).

    Google Scholar 

  9. T. J. Williams,Prostaglandin E 2 ,prostaglandin I 2 and the vascular changes in inflammation. Br. J. Pharmac.65, 517–524 (1979).

    Google Scholar 

  10. T. J. Williams and P. J. Jose,Mediation of increased vascular permeability after complement activation; histamine-independent action of rabbit C5a. J. Exp. Med.153, 136–153 (1981).

    Google Scholar 

  11. C. V. Wedmore and T. J. Williams,Control of vascular permeability by polymorphonuclear leukocytes in inflammation. Nature289, 646–650 (1981).

    Google Scholar 

  12. T. J. Williams and M. J. Peck,Role of prostaglandin-mediated vasodilatation in inflammation. Nature270, 530–532 (1977).

    Google Scholar 

  13. H. J. Muller-Eberhard, The complement system. InThe Plasma Proteins, Vol. I, pp. 393–432 (Ed. F. W. Putnam). Academic Press, London (1975).

    Google Scholar 

  14. T. E. Hugli and H. J. Muller-Eberhard,Anaphylatoxins: C3a and C5a. Adv. Immunol.26 1–53 (1978).

    Google Scholar 

  15. T. J. Williams,A proposed mediator of increased vascular permeability in acute inflammation in the rabbit. J. Physiol. (Lond.)281, 44P (1978).

  16. P. J. Jose, M. J. Forrest and T. J. Williams,Human C5a des Arg increases vascular permeability. J. Immunol.127, 1276–1280 (1981).

    Google Scholar 

  17. C. G. Cochrane, H. J. Muller-Eberhard and B. S. Aikin,Depletion of plasma complement in vivo by a protein of cobra venom: its effect on various immunologic reactions, J. Immunol.105, 55–69 (1970).

    Google Scholar 

  18. C. A. Stetson,Similarities in the mechanisms determining the Arthus and Shwartzman phenomena. J. Exp. Med.94, 347–358 (1951).

    Google Scholar 

  19. J. H. Humphrey,The mechanisms of Arthus reactions. I. The role of polymorphonuclear leucocytes and other factors in reversed passive Arthus reactions in rabbits. Br. J. Exp. Pathol.36, 268–282 (1955).

    Google Scholar 

  20. R. N. Pinckard, L. M. McManus and D. J. Hanahan, Chemistry and biology of acetylglyceryl ether phosphorylcholine (platelet-activating factor). InAdvances in Inflammation Research, Vol. 4, pp. 147–180 (Ed. G. Weissmann). Raven Press, New York (1982).

    Google Scholar 

  21. G. Camussi, M. Aglietta, F. Malvasi, C. Tetta, W. Piacibello, F. Sanavio and F. Bussolino,The release of platelet-activating factor from human endothelial cells in culture. J. Immunol.131, 2397–2403 (1983).

    Google Scholar 

  22. C. V. Wedmore and T.J. Williams,Platelet-activating factor (PAF), a secretory product of polymorphonuclear leukocytes, increases vascular permeability in rabbit skin. Br. J. Pharmac.74, 916P (1981).

  23. S.-B. Hwang, M.-H. Lam, T. Biftu and T.-Y. Shen,A synthetic competitive and specific antagonist of platelet-activating factor. Fed. Proc.44, 1435 (1985).

    Google Scholar 

  24. S. Dequand, J. Lefort, J. Deregnaucourt, P. Sedivy, V. Lagente, J. Randon and B. B. Vargfaftig,Inhibition by the PAF acether antagonist 48740 RP of the bronchopulmonary effects of PAF-acether. Int. J. Immunopharmacol.3, 383 (1985).

    Google Scholar 

  25. P. G. Hellewell and T. J. Williams,Suppression of inflammatory oedema in rabbit skin by two PAF antagonists 48740 RP and L-652731. Prostaglandins30, 713 (1985).

    Google Scholar 

  26. P. G. Hellewell and T. J. Williams,Inhibition of allergic inflammation by PAF antagonists in the rabbit. Br. J. Pharmac.86, 527P (1985).

  27. G. Camussi, C. Tetta, F. Bussolino, F. Callagis Cappio, R. Coda, C. Masera and G. Segoloni,Mediators of immunecomplex-induced aggregation of polymorphonuclear neutrophils. II. Platelet-activating factor as the effector substance of immune-induced aggregation. Int. Archs. Allergy. appl. Immunol.64, 25–41 (1981).

    Google Scholar 

  28. T. J. Williams and P. J. Piper,The action of chemically pure SRS-A on the microvasculature in vivo, Prostaglandins19, 779–789 (1980).

    Google Scholar 

  29. J. M. Drazen, K. F. Austen, R. A. Lewis, D. A. Clark, G. Goto, A. Marfat and E. J. Corey,Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc. Natl. Acad. Sci. USA.77, 4354–4358 (1980).

    Google Scholar 

  30. M. J. Peck, P. J. Piper and T. J. Williams,The effect of leukotrienes C 4 and D 4 on the microvasculature of guinea-pig skin, Prostaglandins21, 315–321 (1981).

    Google Scholar 

  31. P. A. Ward and J. H. Hill,C5 chemotactic fragments produced by an enzyme in lysosomal granules of neutrophils. J. Immunol.104, 535–543 (1970).

    Google Scholar 

  32. P. A. Ward and J. H. Hill,Biologic role of complement products. Complement-derived leukotactic activity extractable from lesions of immunologic vasculitis. J. Immunol.108, 1137–1145 (1972).

    Google Scholar 

  33. J. C. Fantone, S. L. Kunkel and P. A. Ward,Chemotactic mediators in neutrophil-dependent lung injury. Ann. Rev. Physiol.44, 283–293 (1982).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Vascular Biology, MRC Clinical Research Centre, Watford Road, Harrow, Middlesex, U.K.

    T. J. Williams, P. G. Hellewell & P. J. Jose

Authors
  1. T. J. Williams
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. G. Hellewell
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. J. Jose
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Williams, T.J., Hellewell, P.G. & Jose, P.J. Inflammatory mechanisms in the Arthus reaction. Agents and Actions 19, 66–72 (1986). https://doi.org/10.1007/BF01977260

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01977260

Keywords

Search

Navigation