Skip to main content
SpringerLink
Log in

Studies on the biochemical effects of glibenclamide on alloxan diabetic rabbits

  • Published:
Experientia Aims and scope Submit manuscript

Summary

Treatment of alloxan diabetic rabbits with glibenclamide, the most potent of the sulfonylureas, for a period of 2 months, significantly ameliorated the diabetic condition. It produced a decrease in serum and liver lipids, amino acids, serum urea, blood sugar and urine sugar; increase in body weight, serum and liver proteins, liver glycogen, glucose tolerance and serum and liver acid labile phosphates. The possible mechanism of action of this hypoglycemic agent is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. J.C. Shipp, F.C. Wood and M. Alexander, J. Am. med. Ass.188, 468 (1964).

    Article  CAS  Google Scholar 

  2. A.D. Perret, A.S. Rowe, M. Shahmanesh, S.P. Allison and M. Hartog, Diabetologia10, 115 (1974).

    Article  Google Scholar 

  3. R.S. Raheja, Lancet1, 495 (1976).

    Article  CAS  PubMed  Google Scholar 

  4. A. Kopf, G. Tchobroutsky and E. Eschwege, Diabetes22, 834 (1973).

    Article  CAS  PubMed  Google Scholar 

  5. K. Prasannan and K.T. Augusti, Indian J. med. Res.61, 1072 (1973).

    CAS  PubMed  Google Scholar 

  6. A.V. George and K.T. Augusti, Experientia32, 846 (1976).

    Article  CAS  PubMed  Google Scholar 

  7. A. Loubatieres, M.M. Mariani, G. Ribes, D. Malbose and J. Chapal, Diabetologia5, 1 (1969).

    Article  CAS  PubMed  Google Scholar 

  8. H.D. Brahmachari and K.T. Augusti, J. pharm. Pharmac.14, 617 (1962).

    Article  CAS  Google Scholar 

  9. Benedict, J. Am. med. Ass.57, 1193 (1911).

    Article  Google Scholar 

  10. P.T. Mathew and K.T. Augusti, Indian J. Biochem. Biophys.10, 209 (1973).

    CAS  PubMed  Google Scholar 

  11. A. Asatoor and E.J. King, Biochem. J. 56, 44 (1954).

    Article  Google Scholar 

  12. M. Somogyi, J. biol. Chem.195, 19 (1952).

    Article  CAS  Google Scholar 

  13. C. Entenman, in: Methods in Enzymology, vol. 3, p. 299. Ed. S.P. Colowick and N.O. Kaplan. Academic Press, New York 1957.

    Chapter  Google Scholar 

  14. J.J. Carr and I.J. Drekter, Clin. Chem.2, 353 (1956).

    Article  CAS  PubMed  Google Scholar 

  15. D.B. Zilversmit and A.K. Davis, J. Lab. clin. Med.35, 152 (1950).

    Google Scholar 

  16. E. van Handel and D.B. Zilversmit, J. Lab. clin. Med.50, 152 (1957).

    PubMed  Google Scholar 

  17. V.P. Dole, J. clin. Invest.35, 150 (1956).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. N.V. Carrol, R.W. Longley and J.H. Roe, J. biol. Chem.220, 583 (1956).

  19. C.H. Fiske and Y. Subba Row, J. biol. Chem.66, 375 (1925).

    Article  CAS  Google Scholar 

  20. L.F. Leloir and C.E. Cardini, in: Methods in Enzymology, vol. 2, p. 843. Ed. S.P. Colowick and N.O. Kaplan. Academic Press, New York 1957.

    Google Scholar 

  21. J.G. Reinhold, Stand. Meth. clin. Chem.1, 88 (1953).

    CAS  Google Scholar 

  22. Sahyun, J. Lab. clin. Med.24, 548 (1938–39).

    CAS  Google Scholar 

  23. E.G. Frame, J.A. Russel and A.E. Wilhemi, J. biol. Chem.149, 255 (1943).

    Article  CAS  Google Scholar 

  24. S. Natelson, in: Microtechnique of Clinical Chemistry for Routine Laboratory, p. 381. Ed. C.C. Thomas. Springfield, Illinois 1957.

    Google Scholar 

  25. C.A. Bennet and N.L. Franklin, Statistical Analysis in Chemistry and Chemical Industry. John Wiley, New York 1967.

    Google Scholar 

  26. A. Loubatieres, Proc. R. Soc. Med.53, 595 (1960).

    CAS  PubMed  Google Scholar 

  27. A. Hasselblatt, Metabolism12, 302 (1963).

    CAS  Google Scholar 

  28. H.N. Antoniaes, H.M. Pyle and J.A. Bougas, Diabetes11, 34 (1962).

    Google Scholar 

  29. M.B. Bhide and R. Aiman, Indian J. med. Res.51, 733 (1963).

    CAS  PubMed  Google Scholar 

  30. C.R. Lopex Quijada, R. Candela and L.R. Candela, Med. Exp.6, 65 (1962).

    Google Scholar 

  31. R.E. Miller, F.E. Wherry and J.W. Mason, Endocrinology79, 207 (1966).

    Article  CAS  PubMed  Google Scholar 

  32. R.F. Bradley, Ann. N.Y. Acad. Sci.82, 513 (1959).

    Article  CAS  PubMed  Google Scholar 

  33. K.A. George, K.T. Augusti and V.C.M. Roy, Indian J. exp. Biol.16, 1052 (1978).

    CAS  PubMed  Google Scholar 

  34. J.M. Foy and V.F. Standing, Experientia29, 1006 (1973).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Kerala, Trivandrum, India

    P. T. Annamala & K. T. Augusti

Authors
  1. P. T. Annamala
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. T. Augusti
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Annamala, P.T., Augusti, K.T. Studies on the biochemical effects of glibenclamide on alloxan diabetic rabbits. Experientia 36, 383–384 (1980). https://doi.org/10.1007/BF01975099

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01975099

Keywords

Search

Navigation