Skip to main content
SpringerLink
Log in

Release of active substances during anaphylaxis

  • Published:
Agents and Actions Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. K.F. Austen,Reaction Mechanisms in the Release of Mediators of Immediate Hypersensitivity from Human Lung Tissue, Fed. Proc.33, 2256–2262 (1974).

    PubMed  Google Scholar 

  2. J.F. Burka andP. Eyre,The Immunological Release of Slow-Reacting Substance of Anaphylaxis from Bovine Lung, Can. J. Physiol. Pharmac.52, 1201–1204 (1974).

    Google Scholar 

  3. W.E. Brocklehurst,The Probable Role of Known Mediators in Hypersensitivity Reactions, in:Immunopharmacology (Ed. H.O. Schild; Pergamon, Oxford 1968), p. 67–75.

    Google Scholar 

  4. P.J. Piper andJ.R. Vane Release of Additional Factors in Anaphylaxis and Its Antagonism by Anti-Inflammatory Drugs, Nature223, 29–35 (1969b).

    PubMed  Google Scholar 

  5. P.J. Piper andJ.L. Walker,Release of Spasmogenic Substances from Human Chopped Lung Tissue and Its Inhibition, Br. J. Pharmac.47, 291–304 (1973).

    Google Scholar 

  6. W. Dawson andR. Tomlinson,Effect of Cromoglycate and Eicosatetraynoic Acid on the Release of Prostaglandins and SRS-A from Immunologically Challenged Guinea-Pig Lungs, Br. J. Pharmac.52, 107–108P (1974).

    Google Scholar 

  7. W.E. Brocklehurst andS.C. Lahiri,The Production of Bradykinin in Anaphylaxis, J. Physiol.160, 15–16P (1962).

    Google Scholar 

  8. P. Eyre andA.J. Lewis,Production of Kinins in Bovine Anaphylactic Shock, Br. J. Pharmac.44, 311–313 (1972).

    Google Scholar 

  9. O. Jonasson andE.L. Becker,Release of Kallikrein from Guinea-Pig Lung during Anaphylaxis, J. exp. Med.123, 509–522 (1966).

    Article  PubMed  Google Scholar 

  10. A.A. Mathé andL. Levine,Release of Prostaglandins and Metabolites from Guinea-Pig Lung: Inhibition by Catecholamines, Prostaglandins,4, 877–890 (1973).

    Article  PubMed  Google Scholar 

  11. F. Ruff, F. Dray, M.-C. Santais, G. Allouche, C. Foussard, A. Salem andJ.-L. Parrot,Measurements of Pulmonary Prostaglandins, Histamine and Cyclic AMP during Induced Anaphylactic Shock in Guinea-Pig, Abstracts of VI Int. Congress on Pharmacology, Helsinki, July 1975, p. 379.

  12. K. Gréen, P. Hedqvist andN. Svanborg,Increased Plasma Levels of 15-Keto-13,14-dihydroprostaglandin F 2α after Allergen-Provoked Asthma in Man, Lancetii, 1419–1421 (1974).

    Article  Google Scholar 

  13. E. Änggård andB. Samuelsson,Biosynthesis of Prostaglandins from Arachidonic Acid in Guinea-Pig Lung, J. biol. Chem.240, 3518–3521 (1965).

    PubMed  Google Scholar 

  14. H. Kunze andW. Vogt,Significance of Phospholipase A for Prostaglandin Formation, Ann. N.Y. Acad. Sci.180, 123–125 (1971).

    PubMed  Google Scholar 

  15. P.J. Piper andJ.R. Vane,The Release of Prostaglandins from Lung and Other Tissues, Ann. N.Y. Acad. Sci.180, 363–385 (1971).

    PubMed  Google Scholar 

  16. J. Orehek, J.S. Douglas, A.J. Lewis andA. Bouhuys,Prostaglandin Regulation of Airway Smooth Muscle Tone, Nature, New Biol.245, 84–85 (1973).

    Google Scholar 

  17. M.A. Palmer, P.J. Piper andJ.R. Vane,Release of Rabbit Aorta Contracting Substance (RCS) and Prostaglandins Induced by Chemical or Mechanical Stimulation of Guinea-Pig Lungs, Br. J. Pharmac.49, 226–272 (1973).

    Google Scholar 

  18. M. Hamberg, J. Svensson andB. Samuelsson,Novel Transformations of Prostaglandin Endoperoxides: Formation of Thromboxanes. Advances in Prostaglandin and Thromboxane Research, vol. I (Eds B. Samuelsson and R. Paoletti; Raven Press, New York 1976), p. 19–27.

    Google Scholar 

  19. P.J. Piper, H.O.J. Collier andJ.R. Vane,Release of Catecholamines in the Guinea-Pig by Substances Involved in Anaphylaxis, Nature213, 838–840 (1967).

    PubMed  Google Scholar 

  20. J.W. Black, W.A.M. Duncan, C.J. Durant, C.R. Ganellin andE.M. Parsons,Definition and Antagonism of Histamine Receptors, Nature236, 385–390 (1972).

    PubMed  Google Scholar 

  21. J.E. Mills, H. Sellick andJ.G. Widdicombe,Activity of Lung Irritant Receptors in Pulmonary Micro-Embolism, Anaphylaxis and drug-Induced Bronchoconstrictions, J. Physiol., Lond.203, 337–358 (1969).

    Google Scholar 

  22. W.E. Brocklehurst,The Release of Histamine and Formation of a Slow-Reacting Substance (SRS-A) during Anaphylactic Shock, J. Physiol., Lond.151, 416–435 (1960).

    Google Scholar 

  23. P.A. Berry andH.O.J. Collier,Bronchoconstrictor Action and Antagonism of Slow-Reacting Substance from Anaphylaxis of Guinea-Pig Lung, Br. J. Pharmac.23, 201–216 (1964).

    Google Scholar 

  24. J.M. Drazen, D.J. Imming, D.J. Stechschulte, M.O. Amdur, K.F. Austen andJ. Mead,Effects of Intravenous Slow-Reacting Substance of Anaphylaxis (SRS-A) on Respiratory Mechanism, Fed. Proc.32, 402 (Abstr.) (1973).

    Google Scholar 

  25. J.G. Widdicombe,Regulation of Tracheobronchial Smooth Muscle, Physiol. Rev.43, 1–37 (1963).

    PubMed  Google Scholar 

  26. H.O.J. Collier, J.A. Holgate, M. Schachter andP.G. Shorley,The Bronchoconstrictor Action of Bradykinin in the Guinea-Pig, Br. J. Pharmac.15, 290–297 (1960).

    Google Scholar 

  27. D.T. Okpako,A Dual Action of Histamine on Guinea-Pig Lungs Vessels, Br. J. Pharm.45, 311–321 (1972).

    Google Scholar 

  28. K. Greeff andE. Moog, Vergleichende Untersuchungen über die bronchokonstriktorische und gefässkonstriktorische Wirkung des Bradykinins, Histamins und Serotonins an isolierten Lungenpräparaten, Naunyn-Schmiedebergs Arch. Pharmak. exp. Path.248, 204–215 (1964).

    Google Scholar 

  29. W.J.F. Sweatman andH.O.J. Collier,Effects of Prostaglandins on Human Bronchial Muscle, Nature217, 69 (1968).

    PubMed  Google Scholar 

  30. W. Dawson, R.L. Lewis, R.E. McMahon andW.J.F. Sweatman,Protent Bronchoconstrictor Activity of 15-Keto Prostaglandin F 2α . Nature250, 331–332 (1974).

    PubMed  Google Scholar 

  31. D.J. Crutchley andP.J. Piper,Comparative Bioassay of Prostaglandin E 2 and Its Three Pulmonary Metabolites, Br. J. Pharmac.54, 397–399 (1975).

    Google Scholar 

  32. T.J. Williams andJ. Morley,Prostaglandins as Potentiators of Increased Vascular Permeability in Inflammation. Nature246, 215–217 (1973).

    PubMed  Google Scholar 

  33. R. Benzie, J.R. Boot andW. Dawson,A Preliminary Investigation of Prostaglandin Synthetase Activity in Normal Sensitized and Challenged Sensitized Guinea-Pig Lungs, J. Physiol., in press (1975).

  34. S.I. Said, T. Yoshida, S. Kitamura andC. Vreim.Pulmonary Alveolar Hypoxia: Release of Prostaglandins and Other Humoral Mediators, Science185, 1181–1183 (1974).

    PubMed  Google Scholar 

  35. J.L. Walker,The Regulatory Role of Prostaglandins in the Release of Histamine and SRS-A from Passively Sensitized Human Lung Tissue, in:Advances in the Biosciences, vol. 9 (Eds S. Bergström and S. Bernhard; Pergamon Press, Vieweg, Braunschweig 1973) p. 235–239.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, Lincoln's Inn Fields, WC2A 3PN, London

    P. J. Piper

Authors
  1. P. J. Piper
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Piper, P.J. Release of active substances during anaphylaxis. Agents and Actions 6, 547–550 (1976). https://doi.org/10.1007/BF01973278

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01973278

Keywords

Search

Navigation