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Changes in rectal temperature of the rabbit by intracerebroventricular injection of bradykinin and related kinins

  • Histamine and Kinins
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Abstract

The effects of intracerebrovascular injections of bradykinin (BK), lysyl-bradykinin (L-BK), methionyl-lysyl-bradykinin (ML-BK) and des-arginyl-bradykinin (Des-Arg9-BK) on the rectal temperature of rabbits were investigated. A linear dose-response curve could be obtained with bradykinin. Equimolar doses to BK of L-BK and ML-BK gave responses of the rectal temperature undistinguishable from those of BK. In contrast, the smaller polypeptide Des-Arg9-BK did not show any hyperthermic properties. Since prostaglandins (PG) are known to potentiate (facilitate) the peripheral effects of BK and display a hyperthermic action, their synthesis being inhibited by antipyretics, we studied the effect of indomethacin and paracetamol on the BK-induced rise in rectal temperature in rabbits. It could be shown that these drugs inhibited partially the response to BK. The possible participation of BK in thermoregulation will be discussed.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Pharmacy and Dentistry of Ribeirão Preto, 14100, Ribeirão Preto, São Paulo, Brazil

    T. C. Almeida e Silva (Fellow of FAPESP) & I. R. Pelá

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  1. T. C. Almeida e Silva
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  2. I. R. Pelá
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Work aided in part by grant from FAPESP, São Paulo, Brazil.

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Almeida e Silva, T.C., Pelá, I.R. Changes in rectal temperature of the rabbit by intracerebroventricular injection of bradykinin and related kinins. Agents and Actions 8, 102–107 (1978). https://doi.org/10.1007/BF01972410

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