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Susceptibility ofMycobacterium kansasii to ethambutol and its combination with rifamycins, ciprofloxacin and isoniazid

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Abstract

The susceptibility ofMycobacterium kansasii to antibacterial agents alone and in combination was studied. Widespread resistance to ethambutol, ciprofloxacin and isoniazid was found when these drugs were tested separately. However, pronounced antibacterial effects were seen when ethambutol was tested in combination with ciprofloxacin, rifampicin or rifabutin, which corresponded to significantly decreased resistance to these drugs in combination.

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References

  1. Hoffner SE, Svenson SB, Källenius G Synergistic effects of antimycobacterial drugs onMycobacterium avium complex determined radiometrically in liquid medium. European Journal of Clinical Microbiology 1987, 6: 530–535.

    PubMed  Google Scholar 

  2. Hoffner SE, Kratz M, Olsson-Liljequist B, Svenson SB, Källenius G In vitro synergistic activity between ethambutol and flourinated quinolones againstMycobacterium avium complex. Journal of Antimicrobial Chemotherapy 1989, 24: 317–324.

    PubMed  Google Scholar 

  3. Kubín M, Svandová E, Medek B, Chobot S, Olsovsky Z Mycobacterium kansasii infections in an endemic area of Czechoslovakia. Tubercle 1980, 61: 107–112.

    Google Scholar 

  4. Middlebrook G, Reggiardo Z, Tigertt WD Automatable radiometric detection of growth ofMycobacterium tuberculosis in selective media. American Reviews of Respiratory Diseases 1977, 115: 1066–1069.

    Google Scholar 

  5. Heifets LB, Iseman MD Determination of in vitro susceptibility of mycobacteria to ansamycin. American Reviews of Respiratory Diseases 1985, 132: 710–711.

    Google Scholar 

  6. Good RC, Silcox VA, Kilburn JO, Plikaytis BD Identification and drug susceptibility test results forMycobacterium spp. Clinical Microbiology Newsletter 1985, 7: 133–136.

    Google Scholar 

  7. Heifets LB, Iseman MD, Lindholm-Levy PJ, Kanes W Determinations of ansamycin MICs forMycobacterium avium complex in liquid medium by radiometric and conventional methods. Antimicrobial Agents and Chemotherapy 1985, 28: 565–578.

    PubMed  Google Scholar 

  8. David HL Basis for lack of drug susceptibility of atypical mycobacteria. Reviews of Infectious Diseases 1981, 3: 878–884.

    PubMed  Google Scholar 

  9. Rastogi N, Frehel C, Ryter A, Ohayon H, Lesourd M, David HL Multiple drug resistance inMycobacterium avium: is the wall architecture responsible for exclusion of antimicrobial agents? Antimicrobial Agents and Chemotherapy 1981, 20: 666–677.

    PubMed  Google Scholar 

  10. Hoffner SE, Källenius G, Beezer AE, Svenson SB Studies on the mechanisms of the synergistic effects of ethambutol and other antibacterial drugs onMycobacterium avium complex. Acta Leprologica 1989, 7, Supplement 1: 195–199.

    PubMed  Google Scholar 

  11. Källenius G, Svenson SB, Hoffner SE Ethambutol: a key forMycobacterium avium complex chemotherapy? American Reviews of Respiratory Diseases 1989, 140: 264.

    Google Scholar 

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Authors and Affiliations

  1. Department of Bacteriology, National Bacteriological Laboratory, S-105 21, Stockholm, Sweden

    U. Hjelm & S. E. Hoffner

  2. Regional Institute for Hygiene, Ostrava

    J. Kaustová

  3. Institute of Hygiene and Epidemiology, Prague, Czechoslovakia

    M. Kubín

Authors
  1. U. Hjelm
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  2. J. Kaustová
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  3. M. Kubín
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  4. S. E. Hoffner
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Hjelm, U., Kaustová, J., Kubín, M. et al. Susceptibility ofMycobacterium kansasii to ethambutol and its combination with rifamycins, ciprofloxacin and isoniazid. Eur. J. Clin. Microbiol. Infect. Dis. 11, 51–54 (1992). https://doi.org/10.1007/BF01971272

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  • DOI: https://doi.org/10.1007/BF01971272

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