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Role of T lymphocytes in murine collagen induced arthritis

  • Autoimmune Models of Tissue Destruction
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References

  1. D. E. Trentham, A. S. Townes and A. H. Kang,Autoimmunity to type II collagen: an experimental model of arthritis. J. Exp. Med.146, 857–868 (1977).

    Article  PubMed  Google Scholar 

  2. J. S. Courtenay, M. J. Dallman, A. D. Dayan, A. Martin and B. Mosedale,Immunization against heterologous type II collagen induces arthritis in mice. Nature283, 666–668 (1980).

    Article  PubMed  Google Scholar 

  3. E. S. Cathcart, W. A. Gonnerman, K. C. Hayes, V. Agnello, A. A. Lazzari and C. Franzblau,Experimental arthritis in a nonhuman primate. I. Induction by bovine type II collagen. Lab. Invest.54, 26–31 (1986).

    PubMed  Google Scholar 

  4. P. H. Wooley, H. S. Luthra, J. M. Stuart and C. S. David,Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I-region) linkage and antibody correlates. J. Exp. Med.154, 688–700 (1981).

    Article  PubMed  Google Scholar 

  5. P. H. Wooley, A. M. Dillon, H. S. Luthra, J. M. Stuart and C. S. David,Genetic control of type II collagen induced arthritis in mice: factors influencing disease susceptibility and evidence for multiple MHC-associated gene control. Transpl. Proc. Vol.XV, 180–185 (1983).

    Google Scholar 

  6. P. H. Wooley, H. S. Luthra, M. M. Griffiths, J. M. Stuart, A. Huse and C. S. David,Type II collagen induced arthritis in mice. IV. Variations in immunognetic regulation provide evidence for multiple arthritogenic epitopes on the collagen molecule. J. Immunol.135, 2443–2451 (1985).

    PubMed  Google Scholar 

  7. R. Holmdahl, L. Klareskog, M. Andersson and C. Hansen,High antibody response to autologous type II collage is restricted to H-2 q. Immunogenetics24, 84–89 (1986).

    Article  PubMed  Google Scholar 

  8. R. Holmdahl, L. Jansson and M. Andersson,Female sex hormones suppress development of collagen induced arthritis. Arthritis Rheum. (in press) (1986).

  9. E. D. Murphy and J. B. Roths,A Y-chromosome associated factor in strain BXSB producing accelerated autoimmunity and lymphoproliferation. Arthritis Rheum.22, 1188–1194 (1979).

    PubMed  Google Scholar 

  10. R. Holmdahl, L. Jansson, B. Meyerson and L. Klareskog,Collagen arthritis as a model for estrogen induced protection against T cell dependent inflammatory joint disease. (submitted for publication).

  11. J. M. Stuart, A. S. Townes and A. H. Kang,Nature and specificity of the immune response to collagen in type II collagen induced arthritis in mice. J. Clin. Invest.69, 673–683 (1982).

    PubMed  Google Scholar 

  12. W. C. Watson and A. S. Townes,Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non MHC-loci. J. Exp. Med.162, 1878–1891 (1985).

    Article  PubMed  Google Scholar 

  13. R. Holmdahl, L. Jansson, D. Gullberg, K. Rubin, P.-O. Forsberg and L. Klareskog.Incidence of arthritis and autoreactivity of anti-collagen antibodies after immunization of DBA/1 mice with heterologous and autologous collagen II. Clin. exp. Immunol.62, 639–646 (1985).

    PubMed  Google Scholar 

  14. R. Holmdahl, L. Jansson, E. Larsson, K. Rubin and L. Klareskog,Homologous type II collagen induces chronic and progressive arthritis in mice. Arthritis Rheum.29, 106–113 (1986).

    PubMed  Google Scholar 

  15. R. Holmdahl, K. Rubin, L. Klareskog, E. Larsson and H. Wigzell,Characterization of the antibody response in mice with type II collagen induced arthritis, using monoclonal anti-type II collagen antibodies. Arthritis Rheum.29, 400–410 (1986).

    PubMed  Google Scholar 

  16. J. M. Stuart, A. S. Townes and A. H. Kang,Collagen autoimmune arthritis. Ann. Rev. Immunol.2, 199–218 (1984).

    Article  Google Scholar 

  17. L. Klareskog, R. Holmdahl, E. Larsson and H. Wigzell,Role of T-lymphocytes in collagen II induced arthritis in rats. Clin. exp. Immunol.51, 117–125 (1983).

    PubMed  Google Scholar 

  18. R. Holmdahl, K. Rubin, L. Klareskog, L. Dencker, G. Gustafsson and E. Larsson,Appearence of different lymphoid cells in synovial tissue and in peripheral blood during the course of collagen II induced arthritis in rats. Scand. J. Immunol.21, 197–204 (1985).

    PubMed  Google Scholar 

  19. G. E. Ranges, S. Sriram, and S. M. Cooper,Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4. J. Exp. Med.162, 1105–1110 (1985).

    Article  PubMed  Google Scholar 

  20. S. E. Helfgott, H. Bazin, A. Dessein and D. E. Trentham,Suppressive effects of anti-μ serum on the development of collagen arthritis in rats. Clin. Immunol. Immunopathol.31, 403–411 (1984).

    Article  PubMed  Google Scholar 

  21. K. Morgan, R. B. Clague, M. J. Shaw, S. A. Firth, T. M. Twose and P. J. L. Holt,Native type II collagen-induced arthritis in the rat: the effect of complement depletion by cobra venom factor. Arthritis Rheum.24, 1356–1362 (1981).

    PubMed  Google Scholar 

  22. D. E. Trentham, R. A. Dynesius and J. R. David,Passive transfer by cells of type II collagen-induced arthritis in rats. J. Clin. Invest.62, 359–366 (1978).

    PubMed  Google Scholar 

  23. S. M. Helfgott, R. Dynesius-Trentham, E. Brahn and D. E. Trentham,An arthritogenic lymphokine in the rat. J. Exp. Med.162, 1531–1545 (1985).

    Article  PubMed  Google Scholar 

  24. J. M. Stuart, M. A. Cremer, A. S. Townes and A. H. Kang,Type II collagen induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis. J. Exp. Med.155, 1–16 (1982).

    Article  PubMed  Google Scholar 

  25. J. M. Stuart and F. J. Dixon,Serum transfer of collagen-induced arthritis in mice. J. Exp. Med.158, 378–393 (1983).

    Article  PubMed  Google Scholar 

  26. R. Holmdahl, T. Moran and M. Andersson,A rapid and efficient immunization protocol for production of monoclonal antibodies reactive with autoantigens. J. Immunol. Methods83, 379–384 (1985).

    Article  PubMed  Google Scholar 

  27. M. H. Schreier, N. N. Iscove, R. Tees, L. Aarden and H. von Boehmer,Clones of killer and helper T cells: growth requirements, specificity and retention of function in long term culture. Immunol. Rev.51, 315–336 (1980).

    PubMed  Google Scholar 

  28. A. Ben Nun and I. R. Cohen,Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: Process of selection of lines and characterizations of the cells. J. Immunol.129, 303–310 (1982).

    PubMed  Google Scholar 

  29. A. Ben Nun, H. Wekerle and I. R. Cohen,The rapid isolation of clonable antigen specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol.11, 195–199 (1981).

    PubMed  Google Scholar 

  30. R. Maron, R. Zerubavel, A. Friedman and I. R. Cohen,T Lymphocyte line specific for thyroglobulin produces or vacinates against autoimmune thyroiditis in mice. J. Immunol.131, 2316–2322 (1983).

    PubMed  Google Scholar 

  31. J. Holoshitz, Y. Naparstek, A. Ben-Nun and I. R. Cohen,Lines of T lymphocytes induce or vaccinate against autoimmune arthritis. Science219, 56–60 (1983).

    PubMed  Google Scholar 

  32. C. Linington, S. Izumo, M. Suzuki, K. Uyemura, R. Meyerman and H. Wekerle,A permanent rat T cell line that mediates experimental allergic neuritis in the Lewis rat in vivo. J. Immunol.133, 1946–1950 (1984).

    PubMed  Google Scholar 

  33. J. Trotter, S. Sriram, L. Rassenti, C.-H. Chou, R. B. Fritz and L. Steinman,Characterization of T cell lines and clones from SJL/J and (Balb/cxSJL/J)F 1 mice specific for myelin basic protein. J. Immunol.134, 2322–2327 (1985).

    PubMed  Google Scholar 

  34. J. Hall,The study of circulating lymphocytes in vivo, a personal view of artifice and artifact. Immunol. Today6, 149–152 (1985).

    Article  Google Scholar 

  35. R. Holmdahl,Collagen induced arthritis; pathogenetic mechanisms and relevance for rheumatoid arthritis. Comprehensive summaries of Uppsala dissertations from the faculty of Medicine 2 (1985).

  36. R. Holmdahl, L. Klareskog, K. Rubin, E. Larsson and H. Wigzell,T lymphocytes in collagen II induced arthritis in mice. Characterization of arthritogenic collagen II specific T cell lines and clones. Scand. J. Immunol.22, 295–306 (1985).

    PubMed  Google Scholar 

  37. L. F. Rosenwasser, R. S. Bhatnagar and J. D. Stobo,Genetic control of the murine T lymphocyte proliferative response to collagen: analysis of the molecular and cellular contributions to immunogenicity. J. Immunol.124, 2854–2862 (1980).

    PubMed  Google Scholar 

  38. G. Doria, G. Agarossi and L. Adorini,Selective effects of ionizing radiations on immunoregulatory cells. Immunol. Rev.65, 23–53 (1983).

    Google Scholar 

  39. P. H. Krammer, B. Echtenacher, D. Gemsa, U. Hamann H. Hultner, B. Kaltmann, U. Kees, C. Kubelka and F. Macucci,Immune-interferon (IFN-gamma), macrophageactivating factors (MAFs) and colony stimulating factors (CSFs) secreted by T cell clones in limiting dilution microcultures, long term cultures, and by T cell hybridomas. Immunol. Rev.76, 5–28 (1983).

    PubMed  Google Scholar 

  40. M. G. Scher, D. I. Beller and E. R. Unanue,Demonstration of a soluble mediator that induces exudates rich in Ia-positive macrophages. J. Exp. Med.152, 1684–1698 (1980).

    Article  PubMed  Google Scholar 

  41. M. Nakamura, T. Manser, G. D. N. Pearson, M. J. Daley and M. L. Gefter,Effect of IFN-gamma on the immune response in vivo and on gene expression in vitro. Nature307, 381–382 (1984).

    Article  PubMed  Google Scholar 

  42. L. Klareskog, O. Johnell, A. Hulth, R. Holmdahl and K. Rubin,Reactivity of monoclonal anti-collagen II antibodies with cartilage and synovial tissue in rheumatoid arthritis and osteoarthritis. Arthritis Rheum.29, 730–738 (1986).

    PubMed  Google Scholar 

  43. L. Klareskog, U. Forsum, A. Scheynius, D. Kabelitz and H. Wigzell,Evidence in support of a self-perpetuating HLA-DR dependent delayed type cell reaction in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA,79, 3632–3636 (1982).

    PubMed  Google Scholar 

  44. J. T. Hom, J. M. Stuart and J. M. Chiller,Murine T cells reactive to type II collagen. I. Isolation of lines and clones and characterization of their antigen-induced proliferative responses. J. Immunol.136, 769–775 (1986).

    PubMed  Google Scholar 

  45. J. T. Hom, J. M. Stuart, J. Tovey and J. M. Chiller,Murine T cells reactive to type II collagen. II. Functional characterization. J. Immunol.136, 776–782 (1986).

    PubMed  Google Scholar 

  46. M. Dallman and G. Fathman,Type II collagen-reactive T-cell clones from mice with collagen-induced arthritis. J. Immunol.135, 1113–1118 (1986).

    Google Scholar 

  47. A. Scheynius, R. Holmdahl and L. Klareskog,Diminished activation of T helper cells by antigen presentation with DTH-activated epidermal cells. Immunology (in press) (1986).

  48. J. M. Stuart,Collagen-induced arthritis: A new animal model for the evaluation of antiarthritic drugs. Adv. Inflam. Res.7, 263–277 (1984).

    Google Scholar 

  49. P. Jungers, M. Dougados, C. Pelissier, F. Kuttenn, F. Tron, P. Lesavre and J.-F. Bach,Influence of oral contraceptive therapy on the activity of systemic lupus erythematosus. Arthritis Rheum.25, 618–623 (1982).

    PubMed  Google Scholar 

  50. A. D. Steinberg, K. A. Melez, E. S. Raveche, J. P. Reeves, W. A. Boegel, P. A. Smathers, J. D. Taurog, L. Weinlein and M. Duvic,Approach to the study of the role of sex hormones in autoimmunity. Arthritis Rheum.22, 1170–1176 (1979).

    PubMed  Google Scholar 

  51. C. J. Grossman,Interactions between the gonadal steroids and the immune system. Science227, 257–260 (1985).

    PubMed  Google Scholar 

  52. J. P. Vandenbroucke, H. A. Valkenburg, J. W. Boersma, A. Cats, J. J. M. Festen, O. Huber-Bruning and J. J. Rasker,Oral contraceptives and rheumatoid arthritis: Further evidence for a preventive effect. Lancetii, 839–842 (1982).

    Article  Google Scholar 

  53. S. J. Wingrave and C. R. Kay,Reduction in incidence of rheumatoid arthritis associated with oral contraceptives. Lanceti, 569–571 (1978).

    Google Scholar 

  54. V. C. Neuman, K. A. Grindulis, S. Hubball, B. McConkey and V. Wright,Comparison between penicillamine and sulphasalazine in rheumatoid arthritis: Leeds-Birmingham trial. Br. Med. J.287, 1099–1102 (1983).

    Google Scholar 

  55. A. T. M. M. Ali, G. S. Basran and J. Morley,Mode of action of sulphasalazine: an alternative view. Lanceti, 506–507 (1982).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Medical and Physiological Chemistry, University of Uppsala, Box 575, S-75123, Uppsala, Sweden

    R. Holmdahl, L. Klareskog, K. Rubin & M. Andersson

  2. Division of Pharmacology, Pharmacia, Uppsala, Sweden

    J. Björk & G. Smedegård

  3. Dept. of Oral Pathology, University of Göteborg, Göteborg, Sweden

    R. Johnsson

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Holmdahl, R., Klareskog, L., Rubin, K. et al. Role of T lymphocytes in murine collagen induced arthritis. Agents and Actions 19, 295–305 (1986). https://doi.org/10.1007/BF01971231

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