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Anti-inflammatory properties of 4,5-diphenyl-2-oxazolepropionic acid (oxaprozin)

  • Immunosuppression and Inflammation
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Abstract

The oxazole, oxaprozin has a spectrum of activity in various in vivo and in vitro, chronic and acute inflammatory models in 3 species indicating that it belongs to the general class of non-steroidal anti-inflammatory agents. Possible advantageous features of oxaprozin over existing nonsteroidal anti-inflammatory agents include relative safety, minimal irritant properties on the gastrointestinal tract, long half-life, and uricosuric properties.

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Authors and Affiliations

  1. Immunoinflammatory Pharmacology Section. Research Division, Wyeth Laboratories, Inc., Box 8299, 19101, Philadelphia, Pa, USA

    M. E. Rosenthale, A. J. Begany, A. Dervinis, J. L. Malis, D. A. Shriver, L. J. Datko & M. I. Gluckman

Authors
  1. M. E. Rosenthale
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  2. A. J. Begany
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  3. A. Dervinis
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  4. J. L. Malis
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  5. D. A. Shriver
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  6. L. J. Datko
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  7. M. I. Gluckman
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Rosenthale, M.E., Begany, A.J., Dervinis, A. et al. Anti-inflammatory properties of 4,5-diphenyl-2-oxazolepropionic acid (oxaprozin). Agents and Actions 4, 151–159 (1974). https://doi.org/10.1007/BF01970255

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  • DOI: https://doi.org/10.1007/BF01970255

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