Summary
A convenient method is described for the preparation of 5-S- and 2-S-glutathionyldopa, based on tyrosinase oxidation of dopa in the presence of glutathione. The yields of 5-S, 2-S, and 6-S isomers produced were about 76, 12, and 5%, respectively.
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One of the authors (G.P.) thanks the C.N.R. (P.F. Chimica Fine e Secondaria) for partial financial support.
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Ito, S., Palumbo, A. & Prota, G. Tyrosinase-cytalyzed conjugation of dopa with glutathione. Experientia 41, 960–961 (1985). https://doi.org/10.1007/BF01970033
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DOI: https://doi.org/10.1007/BF01970033