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Ischemia reperfusion injury and histamine release in isolated and perfused guinea-pig heart: Pharmacological interventions

  • Histamine and the Gastrointestinal Tract and Cardiovascular System
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Abstract

Experiments were carried out to provide further information on the biochemical and morphological changes occurring in the guinea-pig heart after multiple ligature and reopening of the left anterior descending (LAD) coronary artery. In isolated perfused guinea-pig heart the reopening of LAD coronary artery leads to a release of histamine related to a loss of metachromasia by cardiac mast cells. The process is associated with malonyldialdehyde (MDA) production, cellular overload of calcium and ventricular arrhythmias which can be modulated by pharmacological interventions.

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Authors and Affiliations

  1. Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Morgagni 65, 50134, Florence, Italy

    E. Masini, F. Gambassi, B. Palmerani, A. Pistelli, L. Carlomagno & P. F. Mannaioni

  2. Department of Animal Biology, University of Florence, Viale Morgagni 65, 50134, Florence, Italy

    S. Bianchi

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  1. E. Masini
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  2. S. Bianchi
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  3. F. Gambassi
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  4. B. Palmerani
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  5. A. Pistelli
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  6. L. Carlomagno
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  7. P. F. Mannaioni
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Masini, E., Bianchi, S., Gambassi, F. et al. Ischemia reperfusion injury and histamine release in isolated and perfused guinea-pig heart: Pharmacological interventions. Agents and Actions 30, 198–201 (1990). https://doi.org/10.1007/BF01969037

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  • DOI: https://doi.org/10.1007/BF01969037

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