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Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis

  • Histamine Metabolism
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Abstract

The CSF of twenty-six patients with multiple sclerosis (MS) and of twelve control persons was analysed for histamine and histamine-N-methyltransferase (HMT) activity. Both in patients with remitting and progressive type of disease the histamine level was about 60% higher than in the controls. On the other hand in both groups of patients the HMT activity was significantly lower (32% and 40% respectively) than that of controls. These results suggest an altered histamine metabolism in MS. This might be associated with the immune reaction in MS brain.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology and Department of Neurology, University of Kuopio, SF-70101, Kuopio 10, Finland

    Leena Tuomisto, Hannu Kilpeläinen & Paavo Riekkinen

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  1. Leena Tuomisto
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  2. Hannu Kilpeläinen
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  3. Paavo Riekkinen
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Tuomisto, L., Kilpeläinen, H. & Riekkinen, P. Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis. Agents and Actions 13, 255–257 (1983). https://doi.org/10.1007/BF01967346

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  • DOI: https://doi.org/10.1007/BF01967346

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