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Involvement of leukotrienes and PAF-acether in the increased microvascular permeability of the rabbit retina

  • Inflammation and Anti-Inflammatories: Miscelaneous Studies
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Abstract

The effects of intravenous injection of PAF-acether and of leukotrienes LTB4 and LTD4 on rabbit retina were determinedin vivo in the unanaesthetized animal. PAF-acether induced an intense ischemia accompanied by a marked plasma leakage. The extravasation remained both in the platelet-depleted rabbit where a sludge phenomenon appeared and in the reserpine-treated animal. Prostacyclin injected after PAF-acether restored only partially the normal retinal appearance.

The effect of LTC4 and LTD4 was markedly less intense than PAF-acether which is not too surprising in this species, given the previous results.

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Authors and Affiliations

  1. IHB Research Laboratories, 17 Avenue Descartes, F. 92350, Le Plessis Robinson, (F)

    P. Braquet

  2. Dept. d'Ophtalmologie, Institut Prophylactique, Rue d'Assas, F 75005, Paris, (F)

    R. F. Vidal

  3. Centre de Recherches du Service de Santé des Armées, I Bis Rue Raoul Batany, F. 92141, Clamart, (F)

    M. Braquet

  4. Clinique Ophtalmologique Universitaire, UER Cochin, 27 Rue du Fbg. St. Jacques, F. 75014, Paris, (F)

    H. Hamard

  5. Unité des Venins, Département de Physiopathologie Expérimentale, Institut Pasteur, 25 Rue du Dr. Roux, F. 75015, Paris, (F)

    B. B. Vargaftig

Authors
  1. P. Braquet
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  2. R. F. Vidal
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  3. M. Braquet
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  4. H. Hamard
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  5. B. B. Vargaftig
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Braquet, P., Vidal, R.F., Braquet, M. et al. Involvement of leukotrienes and PAF-acether in the increased microvascular permeability of the rabbit retina. Agents and Actions 15, 82–85 (1984). https://doi.org/10.1007/BF01966977

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  • DOI: https://doi.org/10.1007/BF01966977

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