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Effect of antiarthritic drugs on the enhanced interleukin-1 (IL-1) production by macrophages from adjuvant-induced arthritic (AA) rats

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Abstract

The effect of antiarthritic drugs on hindpaw edema and enhanced IL-1 production by macrophages from adjuvant arthritic (AA) rats was determined. Hindpaw edema was inhibited by indomethacin (INDO), methotrexate (MTX) or prednisolone (PRED) but not byd-penicillamine (d-PEN) or chloroquine (CQ). IL-1 production by splenic adherent cells was decreased by MTX and PRED; whereas, IL-1 production by peritoneal exudate cells was decreased by PRED, INDO andd-PEN. This normalization in IL-1 production is not caused by a direct inhibition of IL-1 production by the drugs but most likely reflects clinical improvement in the disease. Whether reduction in IL-1 levels provides a more meaningful parameter than paw edema for assessing clinical efficacy of disease-modifying drugs remains to be determined.

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Authors and Affiliations

  1. Smith Kline & French Laboratories, 709 Swedeland Road, 19479, Swedeland, PA, USA

    M. J. DiMartino, W. J. Johnson, B. Votta & N. Hanna

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  1. M. J. DiMartino
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  2. W. J. Johnson
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  3. B. Votta
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  4. N. Hanna
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Code:L-101

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DiMartino, M.J., Johnson, W.J., Votta, B. et al. Effect of antiarthritic drugs on the enhanced interleukin-1 (IL-1) production by macrophages from adjuvant-induced arthritic (AA) rats. Agents and Actions 21, 348–350 (1987). https://doi.org/10.1007/BF01966512

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  • DOI: https://doi.org/10.1007/BF01966512

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