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Taxol inhibits N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced human neutrophil polarization and H2O2 production while decreasing [3H]FMLP binding

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Abstract

We have studied the effect of taxol on two N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced neutrophil functions and the possible mechanism by which it inhibits these functions. Taxol inhibited FMLP-induced human neutrophil polarization (a characteristic change in neutrophil shape in response to a chemotactic stimulus) and H2O2 generation. Taxol also decreased the specific binding of [3H]FMLP to human neutrophils at 4°C. The decreased binding of FMLP to its receptor may be responsible for the inhibition by taxol of FMLP-induced polarization and H2O2 generation.

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Authors and Affiliations

  1. Wellcome Research Laboratories, 27709, Research Triangle Park, NC, USA

    M. A. Iannone, G. Wolberg, R. Reynolds-Vaughn & T. P. Zimmerman

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  1. M. A. Iannone
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  2. G. Wolberg
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  3. R. Reynolds-Vaughn
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  4. T. P. Zimmerman
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Iannone, M.A., Wolberg, G., Reynolds-Vaughn, R. et al. Taxol inhibits N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced human neutrophil polarization and H2O2 production while decreasing [3H]FMLP binding. Agents and Actions 21, 278–280 (1987). https://doi.org/10.1007/BF01966490

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  • DOI: https://doi.org/10.1007/BF01966490

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