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Effects of indomethacin, cyclosporin, cyclophosphamide, and placebo on collagen-induced arthritis of mice

  • Inflammation and Immunomodulation
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Abstract

The long term effects of indomethacin, cyclosporin, cyclophosphamide, and placebo on collagen-induced arthritis in mice were tested under two different treatment protocols. A prophylactic experiment examined the effects of the daily drug administration for 180 days beginning one day before the first collagen injection. Under this dosage schedule, cyclophosphamide and cyclosporin decreased the severity of arthritis, while indomethacin did not. A therapeutic protocol examined the effects of these same drugs when daily administration was delayed until the animals had active disease at 78 days after the first collagen injection. Under this protocol, all three drugs reduced the progression of disease. In both protocols, the most significant suppression of arthritis was seen in animals receiving cyclophosphamide which was associated with a decrease in anti-collagen antibody levels. Collagen-induced arthritis in mice should be further investigated as a model to study the long term effects of “slow-acting” anti-rheumatic drugs.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, University of Utah School of Medicine and Medical Service, Veterans Administration Medical Center, Salt Lake City, Utah, USA

    G. W. Cannon M.D. (Assistant Professor), S. McCall, B. C. Cole (Professor), M. M. Griffiths (Research Associate Professor), L. A. Radov (Principle Investigator) & J. R. Ward (Professor)

  2. Division of Rheumatology, University of Utah, 50 North Medical Drive, 84132, Salt Lake City, Utah, USA

    G. W. Cannon M.D. (Assistant Professor)

  3. VA Medical Center, 50 North Medical Drive, 84132, Salt Lake City, Utah, USA, USA

    G. W. Cannon M.D. (Assistant Professor)

  4. Laboratory Specialist, University of Utah, Salt Lake City, Utah, USA

    S. McCall

  5. Division of Rheumatology, University of Utah, Salt Lake City, Utah, USA

    B. C. Cole (Professor)

  6. Division of Rheumatology, University of Utah and Research Chemist, VA Medical Center, Salt Lake City, Utah, USA

    M. M. Griffiths (Research Associate Professor)

  7. Pharmaceutical Division, Pennwalt Corporation, Rochester, New York, USA

    L. A. Radov (Principle Investigator)

  8. Division of Rheumatology, University of Utah, USA

    J. R. Ward (Professor)

Authors
  1. G. W. Cannon M.D.
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  2. S. McCall
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  3. B. C. Cole
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  4. M. M. Griffiths
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  5. L. A. Radov
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  6. J. R. Ward
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Additional information

Supported in part by a grant from Pennwalt Pharmaceutical Company, Rochester, NY, the Veterans Administration Medical Research program, Nora Eccles Treadwell Foundation, and grants from the National Institutes of Health AR-02255 and AM30763.

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Cannon, G.W., McCall, S., Cole, B.C. et al. Effects of indomethacin, cyclosporin, cyclophosphamide, and placebo on collagen-induced arthritis of mice. Agents and Actions 29, 315–323 (1990). https://doi.org/10.1007/BF01966463

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  • DOI: https://doi.org/10.1007/BF01966463

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