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Quantitative radiographic diagnosis of osteo-arthritis of the knee-joint in the C57BL mouse

  • Inflammation and Immunomodulation
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Abstract

Comparative histopathological and radiographic investigations in the C57BL mouse model of spontaneous osteo-arthritis of the knee-joint indicate that there is a relation between quantitative radiographic diagnosis and semiquantitative histopathological diagnosis. Statistical analysis based on a set of quantitative radiographic parameters of the mouse knee-joint shows that the greater part of the radiographic information reflecting the histopathological degree of the osteo-arthritis is contained in the projection areas of the lateral and medial meniscus: progression of the osteo-arthritic process is accompanied with enlargement of the menisci. On the basis of these observations, a radiography score for the osteo-arthritis has been constructed, which consists of a weighted sum of the — suitably transformed-projection areas of the lateral and medial meniscus. In addition to the size of the menisci, the width of the joint space is also a useful quantitative parameter of osteo-arthritis of the mouse knee-joint.

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Author notes

  1. R. Reife

    Present address: Dept. of Anatomy, University of Tennessee, 875 Monroe Ave., 38163, Memphis, TN, USA

Authors and Affiliations

  1. Pharmaceuticals Division, Ciba-Geigy Limited, K-125.5.16, CH-4002, Basle, Switzerland

    A. Pataki, R. Reife, E. Witzemann & H. P. Graf

  2. Computersysteme Schweizer, Basle, Switzerland

    A. Schweizer

Authors
  1. A. Pataki
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  2. R. Reife
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  3. E. Witzemann
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  4. H. P. Graf
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  5. A. Schweizer
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Pataki, A., Reife, R., Witzemann, E. et al. Quantitative radiographic diagnosis of osteo-arthritis of the knee-joint in the C57BL mouse. Agents and Actions 29, 201–209 (1990). https://doi.org/10.1007/BF01966448

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  • DOI: https://doi.org/10.1007/BF01966448

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