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Cellular events in denervated limb stumps ofAmbystoma larvae during re-innervation and subsequent regeneration

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Summary

Amputated, denervatedAmbystoma forelimbs undergo cellular dedifferentiation and slight resorption through 12 days post-amputation. Subsequently, as limb stumps become re-innervated, there occur mitosis, blastema formation, and regeneration. The initial increase in the mitotic index in once-denervated limb stumps is closely correlated with the presence of ingrowing nerve fibres.

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Authors and Affiliations

  1. Developmental Biology Program and Department of Zoology, The Ohio State University, 43210, Columbus, Ohio, USA

    N. S. Petrosky, R. A. Tassava & C. L. Olsen

Authors
  1. N. S. Petrosky
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  2. R. A. Tassava
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  3. C. L. Olsen
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Additional information

This work was supported by grant PCM 76-11807 from the National Science Foundation.

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Petrosky, N.S., Tassava, R.A. & Olsen, C.L. Cellular events in denervated limb stumps ofAmbystoma larvae during re-innervation and subsequent regeneration. Experientia 36, 601–603 (1980). https://doi.org/10.1007/BF01965826

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