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Effect of cyproheptadine on the octopamine-induced responses in the mammalian central nervous system

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Summary

Extracellular recordings have been made from rat thalamic neurones anaesthetized with urethane, 1.5–2 g/kg i.p. Iontophoretically applied octopamine excited certain thalamic neurones in the ventral basal complex while inhibiting others. Both effects were reversibly antagonized by iontophoretically applied cyproheptadine without affecting responses to noradrenaline and dopamine.

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Authors and Affiliations

  1. School of Biochemical and Physiological Sciences, University of Southampton, SO9 3 TU, Southampson, England

    W. P. C. Dao & R. J. Walker

Authors
  1. W. P. C. Dao
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  2. R. J. Walker
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Additional information

Acknowledgment. We are grateful to Merck, Sharp and Dohme for a gift of cyproheptadine HCl.

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Dao, W.P.C., Walker, R.J. Effect of cyproheptadine on the octopamine-induced responses in the mammalian central nervous system. Experientia 36, 584–585 (1980). https://doi.org/10.1007/BF01965816

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  • DOI: https://doi.org/10.1007/BF01965816

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