Skip to main content
SpringerLink
Log in

Antimitotic effect of nimbidin — A first report

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

The antimitotic activity of nimbidin, a drug from the plantMelia azadirecta indica, was assessed by its effect on the meristematic cells of onion root tips. The effect was almost similar to those of colchicine and vinca alkaloids. Recovery trials showed that the drug induces lethal damage in a considerable proportion of treated cells and may hence have applications in cancer chemotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J.J. Biesele, in: Mitotic poisons and the cancer problem. Elsevier, Amsterdam 1968.

    Google Scholar 

  2. G. Deysson, Int. Rev. Cytol24, 99 (1968).

    Article  CAS  Google Scholar 

  3. E. Boesen and W. Davis, in: Cytotoxic drugs in the treatment of cancer. Edward Arnold, 1969.

  4. A.S. Barclay and R.E. Perdue, Cancer Treat. Rep.60, 1081 (1976).

    CAS  Google Scholar 

  5. A. Levan, Cold Spring Harb. Symp. quant. Biol16, 238 (1949).

    Google Scholar 

  6. S. Siddiqui, Curr. Sci.11, 278 (1942).

    CAS  Google Scholar 

  7. E.J. Abbot, Cancer Treat. Rep.60, 1007 (1976).

    Google Scholar 

  8. A.S. Bajer and J. Mole'bajer, in: Spindle dynamics and chromosome movements. Academic Press, New York 1972.

    Google Scholar 

  9. V.C. Mercykutty and J. Stephen, Cytologia, in press (1981).

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Medical College, 695011, Trivandrum

    G. Santhakumari & J. Stephen

  2. Department of Botany, University of Kerala, Kariavattom, 695581, Trivandrum, India

    G. Santhakumari & J. Stephen

Authors
  1. G. Santhakumari
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Stephen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Santhakumari, G., Stephen, J. Antimitotic effect of nimbidin — A first report. Experientia 37, 91–93 (1981). https://doi.org/10.1007/BF01965589

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01965589

Keywords

Search

Navigation