Skip to main content
SpringerLink
Log in

Effect of prostaglandins and dibutyryl cyclic AMP on the morphology of cells in primary astroglial cultures and on metabolic enzymes of GABA and glutamate metabolism

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Prostaglandins (PGE1) and dibutyryl cyclic AMP (dBc AMP) induce similar morphological changes in astrocytes obtained in primary cultures. PGE1 and dBc AMP increased 2 enzymes of GABA and glutamate metabolism, GABA-T and AAT, but did not modify GDH and GLN-S. Prostaglandins probably affect the cAMP content of glial cells and act in the same way as dBc AMP on glial cell differentiation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

AAT:

aspartate aminotransferase (EC 2.6.1.1)

GDH:

glutamate dehydrogenase (EC 1.4.1.3.)

GLN-S:

glutamine synthetase (EC 6.3.1.2.)

GABA-T:

GABA-transaminase (EC 2.6.1.19.)

GAD:

6L-glutamate decarboxylase (EC 4.1.1.15.)

PLP:

pyridoxal phosphate

GFA:

glial fibrillary acidic protein

dBc AMP:

dibutyryl cyclic AMP

FCS:

foetal calf serum

PGE1 :

prostaglandins I type

References

  1. L. Latzkovits, M. Sensenbrenner and P. Mandel, J. Neurochem.23, 193 (1974).

    Article  CAS  Google Scholar 

  2. E. Bock, M. Møller, C. Nissen and M. Sensenbrenner, Febs Lett.83, 207 (1977).

    Article  CAS  Google Scholar 

  3. J. Bardakdjian, M. Tardy, C. Pimoule and P. Gonnard, Neurochem. Res.4, 517 (1979).

    Article  CAS  Google Scholar 

  4. M. Tardy, J. Bardakdjian and P. Gonnard, Adv. exp. Med. Biol.123, 177 (1978).

    Article  CAS  Google Scholar 

  5. K. N. Prasad, Nature New Biol236, 49 (1972).

    Article  CAS  Google Scholar 

  6. P. P. Gonnard, A. Wicker, J. C. Kouyoumdjian and M. Bloch-Tardy, Biochimie55, 509 (1973).

    Article  CAS  Google Scholar 

  7. S. Berl, Biochemistry5, 916 (1966).

    Article  CAS  Google Scholar 

  8. O. H. Lowry, N. J. Rosebrough, A. L. Farr and R. J. Randall, J. biol. Chem.193, 265 (1951).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Département de Biochimie, C. H. U. Henri-Mondor, 51, Avenue de Lattre-de-Tassigny, F-94010, Créteil Cédex, France

    M. Tardy, C. Fages, B. Rolland, J. Bardakdjian & P. Gonnard

Authors
  1. M. Tardy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Fages
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Rolland
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Bardakdjian
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Gonnard
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tardy, M., Fages, C., Rolland, B. et al. Effect of prostaglandins and dibutyryl cyclic AMP on the morphology of cells in primary astroglial cultures and on metabolic enzymes of GABA and glutamate metabolism. Experientia 37, 19–21 (1981). https://doi.org/10.1007/BF01965545

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01965545

Keywords

Search

Navigation