Abstract
The anti-histaminic drugs ketotifen and oxatomide have a dual effect on rat peritoneal mast cells. At high concentrations they induce histamine release, whereas at low concentrations they inhibit secretion evoked by IgE-directed ligands. The latter effect is observed in the presence and absence of exogenous calcium. The significance of this result for the general mode of action of anti-anaphylactic drugs is discussed. Neither compound liberates histamine from isolated mesenteric cells from the rat or guinea pig, further emphasizing the functional heterogeneity of mast cells from different sources.
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Truneh, A., White, J.R. & Pearce, F.L. Effect of ketotifen and oxatomide on histamine secretion from mast cells. Agents and Actions 12, 206–209 (1982). https://doi.org/10.1007/BF01965147
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DOI: https://doi.org/10.1007/BF01965147