Abstract
In comparison with those in normal (+/+) mice, tissue histamine levels were lower in athymic (nu/nu) female mice and higher in athymic male mice. The sexual difference was less marked or absent in nu/nu mice. These results show (a) that endocrine factors are involved in the distribution of tissue histamine, and (b) that the thymus cannot be considered as the main source of tissue histamine in pathogen-free mice.
Similar content being viewed by others
References
J.W. Combs, D. Lagunoff andE.P. Denditt,Differentiation and proliferation of embryonic cells of the rat, J. Cell Biol.25, 577–592 (1965).
K. Kitamura, M. Shimada, S. Go, H. Matsuda, K. Hatanaka andM. Seki,Distribution of mast-cell precursors in hematopoietic and lymphopoietic tissues of mice, J. Exp. Med.150, 482–490 (1979).
J.W. Combs,An electron microscope study of mouse mast cells arising in vivo and in vitro, J. Cell Biol.48, 676–684 (1971).
H. Ginsburg andD. Lagunoff,The in vitro differentiation of mast cells, J. Cell. Biol.35, 685–697 (1967).
T. Ishizaka, H. Okudaira, L.E. Mauser andK. Ishizaka,Development of rat mast cells in vitro. I. Differentiation of mast cells from thymus cells, J. Immunol.116, 747–754 (1976).
C. Burtin, P. Scheinmann, J.C. Salomon, G. Lespinats, C. Frayssinet, B. Lebel andP. Canu,Increased tissue histamine levels in tumour-bearing mice and rats. Br. J. Cancer43, 684–688 (1981).
P.A. Shore, A. Burkhalter andU.H. Cohn,A method for the fluorometric assay of histamine in tissue, J. Pharmac. Exp. Ther.127, 182–187 (1959).
R. Keller, M.W. Hess andJ.F. Riley,Mast cells in the skin of normal, hairless and athymic mice, Experientia32, 171–172 (1976).
N.R. Lynch, J. Prin andJ.C. Salomon,Passive cutaneous anaphylaxis and vasoactive amine challenge in nude (nu/nu) mice, Immunology32, 89–94 (1977).
D. Guy-Grand, C. Griscelli andP. Vassali,The mouse gut T lymphocyte, a novel type of T cell, J. Exp. Med.148, 1661–1667 (1978).
E.J. Ruitenberg, A. Elgersma andC.H.J. Lamers, Kinetics and characteristics of intestinal mast cells and globule leucocytes. InThe Mast Cell, Its Role in Health and Disease, pp. 732–737 (EdsJ. Pepys andA.M. Edwards). Pitman Medical, London 1979.
B. Lebel, P. Scheinmann, P. Canu andC. Burtin,Histamine levels in mouse tissues of different strains: influence of sex, Agents and Actions10, 149–150 (1980).
P. Scheinmann, B. Lebel, P. Canu andC. Burtin,Histamine levels in mouse tissues: influence of castration, Agents and Actions10, 150–151 (1980).
E.M. Pantelouris andS. Lintern-Moore, Physiological studies of the nude mice. InThe Nude Mouse in Experimental and Clinical Research, pp. 29–48 (EdsJ. Fogh andP. Giovanella). Academic Press, New York 1978.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Burtin, C., Scheinmann, P., Paupe, J. et al. Tissue histamine levels in male and female normal and nude mice. Agents and Actions 12, 199–200 (1982). https://doi.org/10.1007/BF01965144
Issue Date:
DOI: https://doi.org/10.1007/BF01965144