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Intrinsic asthma and bacterial histamine release

  • Histamine and Kinins
  • Histamine and Immunology
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Abstract

In this study of intrinsic asthma (IA) in children the pathogenic role of bacteria in respiratory disease was elucidated by a basophil histamine liberation technique. Several strains of bacteria caused release of histamine from peripheral leukocytesin vitro. Normal, non-infectious and non-atopic children frequently responded in a similar fashion, although positive responses were less frequent. It seems that two different mechanisms of bacterial histamine release exist: interaction with the basophil-bound IgE and a direct interaction with the cell surface. It is suggested that the histamine release takes place only in the lung of IA patients, where a defective pulmonary barrier could permit the bacteria to enter, but not in healthy individuals.

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Authors and Affiliations

  1. Department of Pharmacology, University of Copenhagen, Rigshospitalet and Statens Seruminstitut, Copenhagen, Denmark

    S. Norn, P. Stahl Skov, Chr Kock, P. Andersen, M. Pedersen, P. Tønnesen, P. S. Pedersen, N. E. Møller, J. Hertz & N. Høiby

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  1. S. Norn
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  2. P. Stahl Skov
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  3. Chr Kock
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  4. P. Andersen
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  5. M. Pedersen
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  6. P. Tønnesen
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  7. P. S. Pedersen
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  8. N. E. Møller
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  9. J. Hertz
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  10. N. Høiby
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Norn, S., Skov, P.S., Kock, C. et al. Intrinsic asthma and bacterial histamine release. Agents and Actions 12, 101–102 (1982). https://doi.org/10.1007/BF01965116

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  • DOI: https://doi.org/10.1007/BF01965116

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