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An antiallergic activity of disodium cromoglycate unrelated to mast cell activation

  • Histamine and Kinins
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Abstract

The pharmacological effects of disodium cromoglycate (DSCG) were studied in rats during the development of reactions to various allergens or carrageenin. DSCG (10 mg/kg and 100 mg/kg, i.v.) showed pronounced inhibitory effects on type I and type III (passive Arthus) allergic reactions. An immunological degranulation of mast cells and a significant decrease in tissue histamine content were observed in type I allergic reactions but not in type III allergic reactions characterized by an apparent infiltration of neutrophils. An antihistaminic agent, promethazine (1 mg/kg, i.v.) was effective only against type I allergic reactions and totally ineffective against type III allergic reactions. Thus, the results obtained above strongly suggest that DSCG exhibits at least two mechanisms of antiallergic action; one is related to mediator release from mast cells and the other is unrelated to mast cell activation.

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  1. Kyoto Research Laboratories, Kaken Pharmaceutical Co. Ltd., 14 Minamikawara-Machi, Shinomiya, Yamashina-Ku, 607, Kyoto, Japan

    Kiyoshi Kuriyama, Yoshiyuki Hiyama, Ryoichi Nagatahira, Toshiaki Okuda, Katsuhiro Saito & Kiyoshi Ito

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  1. Kiyoshi Kuriyama
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Kuriyama, K., Hiyama, Y., Nagatahira, R. et al. An antiallergic activity of disodium cromoglycate unrelated to mast cell activation. Agents and Actions 18, 473–478 (1986). https://doi.org/10.1007/BF01964949

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  • DOI: https://doi.org/10.1007/BF01964949

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