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Immunosuppressive effects of Ovalicin-semicarbazone

  • Immunosuppression and Inflammation
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Summary

Ovalicin-semicarbazone suppresses antibody-formation in mice and in other species as measured in the plaque-forming cell and haemagglutination tests. It further impairs cell-mediated immunity as assayed by: homograft reaction and immune cytolysis of tumour target cells in mice, experimental allergic encephalomyelitis in rats, and the tuberculin reaction in guinea-pigs. Although spleen weights are decreased in Ovalicin-semicarbazone treated animals, bone marrow inhibition (as measured by peripheral leukocyte and thrombocyte counts) is only moderate after repeated administration of immunosuppressive doses. Recovery of haemopoietic functions occurs soon after cessation of treatment. The effects of Ovalicinsemicarbazone are compared with those of Ovalicin and azathioprine

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Author notes

  1. S. Lazáry

    Present address: Institute for clinical Immunology, Inselspital, CH-3000, Bern

Authors and Affiliations

  1. Biological and Medical Research Division, Sandoz Ltd., CH-4002, Basle, Switzerland

    J. F. Borel, S. Lazáry & H. Stähelin

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  1. J. F. Borel
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  2. S. Lazáry
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  3. H. Stähelin
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Borel, J.F., Lazáry, S. & Stähelin, H. Immunosuppressive effects of Ovalicin-semicarbazone. Agents and Actions 4, 357–363 (1974). https://doi.org/10.1007/BF01964937

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  • DOI: https://doi.org/10.1007/BF01964937

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