Abstract
The pattern of the mechanical responses elicited in guinea-pig ventricular muscle by histamine was analized and compared with the effect of noradrenaline on the same preparation.
Histamine was more effective than noradrenaline in producing a positive inotropic action: the maximum increase in the contractile force was reached by histamine at smaller concentrations than noradrenaline. Moreover, noradrenaline caused a shortening of the relaxation time which was unaffected by histamine.
Burimamide and metiamide antagonized competitively the inotropic action of histamine leaving unchanged the effect of noradrenaline.
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Moroni, F., Ledda, F., Fantozzi, R. et al. Effects of histamine and noradrenaline on contractile force of guinea-pig ventricular strips: Antagonism by burimamide and metiamide. Agents and Actions 4, 314–319 (1974). https://doi.org/10.1007/BF01964933
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DOI: https://doi.org/10.1007/BF01964933