Abstract
In an open clinical trial, 109 episodes ofPneumocystis carinii pneumonia (70 proven and 39 highly probable) were treated with clindamycin/primaquine. These episodes were in 35 patients who failed on standard therapy and 15 who did not tolerate standard therapy; 59 patients received this regimen as their initial treatment. The clinical outcome was excellent with only 8 cases of failures encountered (6 patients also failed on standard therapy). The onset of clinical response was obvious in less than 72 hours in 81% of patients; the relapse rate was very low. The regimen was well tolerated and compares advantageously with conventional therapy forPneumocystis carinii pneumonia.
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Toma, E. Clindamycin/primaquine for treatment ofPneumocystis carinii pneumonia in AIDS. Eur. J. Clin. Microbiol. Infect. Dis. 10, 210–213 (1991). https://doi.org/10.1007/BF01964467
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DOI: https://doi.org/10.1007/BF01964467