Abstract
In a study to determine the conditions required for its antibacterial activity, zidovudine was found to be bactericidal againstEscherichia coli andSalmonella typhimurium in nutrient broth over 6 h. Zidovudine was also found to be active against ten clinical isolates ofSalmonella andEscherichia coli at 1 mg/l, which is a clinically achievable concentration of the drug. Bacterial protein synthesis was required for the bactericidal activity of zidovudine against bothEscherichia coli andSalmonella typhimurium. Zidovudine was found to be inactive against non-dividing bacteria, as it was unable to kill bacteria of either species when they were suspended in PBS.
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Lewin, C.S., Amyes, S.G.B. Conditions required for the antibacterial activity of zidovudine. Eur. J. Clin. Microbiol. Infect. Dis. 8, 737–741 (1989). https://doi.org/10.1007/BF01963765
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DOI: https://doi.org/10.1007/BF01963765