Abstract
A report is given on two neutropenic patients with staphylococcal septicemia caused byStaphylococcus haemolyticus andStaphylococcus aureus (both strains methicillin-resistant) who failed to respond to therapy with teicoplanin. Both strains were resistant to teicoplanin (MIC 16 and 8 mg/l respectively), but remained sensitive to vancomycin (MIC 2 and 4 mg/l respectively). Replacement of teicoplanin with vancomycin led to full recovery of both patients and their discharge from hospital. These two cases emphasize the importance of clinical and microbiological monitoring of patients with staphylococcal septicemia, even when glycopeptides are used for treatment.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Watanakunakorn C: In vitro induction of resistance in coagulase-negative staphylococci to vancomycin and teicoplanin. Journal of Antimicrobial Chemotherapy 1988, 22: 321–324.
Schwalbe RS, Stapleton JT, Gilligan PH: Emergence of vancomycin resistance in coagulase-negative staphylococci. New England Journal of Medicine 1987, 316: 927–930.
Wilson APR, O'Hare MD, Felmingham D, Grüneberg RN: Teicoplanin-resistant coagulase-negative staphylococcus. Lancet 1986, ii: 973.
Leclercq R, Derlot E, Duval J, Courvalin P.: Plasmid-mediated resistance to vancomycin and teicoplanin inEnterococcus faecium. New England Journal of Medicine 1988, 319: 157–161.
Moore EP, Speller DCE: In vitro teicoplanin resistance in coagulase-negative staphylococci from patients with endocarditis and from a cardiac surgery unit. Journal of Antimicrobial Chemotherapy 1988, 21: 417–424.
Chabbert YA: Antibiotiques en bactériologie médicale. In: Daguet GL, Chabbert YA (ed): Technique en bactériologie. Flammarion, Paris, 1972, p. 143–242.
Courvalin P, Goldstein F, Philippon A, Sirot J; L'antibiogramme. Mpc-Vidéon, Brussels, 1985, p. 191.
Barry AL, Thornsberry C, Jones RN: Evaluation of teicoplanin and vancomycin disk susceptibility tests. Journal of Clinical Microbiology 1986, 23: 100–103.
Low DE, McGeer A, Poon R: Activities of daptomycin and teicoplanin againstStaphylococcus haemolyticus andStaphylococcus epidermidis, including evaluation of susceptibility testing recommendations. Antimicrobial Agents and Chemotherapy 1989, 33: 585–588.
Pizzo PA, Hathorn JW, Hiemenz J, Browne M, Commers J, Cotton D, Gress J, Longo D, Marshall D, McKnight J, Rubin M, Skelton J, Thaler M, Wesley R: A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia. New England Journal of Medicine 1986, 315: 552–558.
Klastersky J, Zinner SH: Synergystic combinations of antibiotics in gram-negative bacillary infections. Reviews of Infectious Diseases 1982; 4: 294–301.
Winston DJ, Gale RP, Meyer DV, Young LS andthe UCLA Bone Marrow Transplantation Group: Infectious complications of human bone-marrow transplantation. Medicine 1979, 58: 1–31.
Meyers JD: Infection in bone-marrow transplant recipients. American Journal of Medicine 1986, 81, Supplement 1A: 27–38.
Whimbey E, Kiehn TE, Brannon P, Blevins A, Armstrong D: Bacteremia and fungemia in patients with neoplastic disease. American Journal of Medicine 1987, 82: 723–730.
Brennan MF, Lowry SF: Nutritional support in the cancer patient. In: Howland WS, Carlon GC (ed): Critical care of the cancer patient. Year Book Medical publishers, Chicago, 1985, p. 275–295.
Mouton RP, Mulders SL; LY 146032: activity and resistance development in vitro. Journal of Antimicrobial Chemotherapy 1987, 20: 513–517.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Brunet, F., Vedel, G., Dreyfus, F. et al. Failure of teicoplanin therapy in two neutropenic patients with staphylococcal septicemia who recovered after administration of vancomycin. Eur. J. Clin. Microbiol. Infect. Dis. 9, 145–147 (1990). https://doi.org/10.1007/BF01963643
Issue Date:
DOI: https://doi.org/10.1007/BF01963643