Abstract
Gastric/duodenal biopsy material from 52 patients was examined immunohistochemically forHelicobacter (Campylobacter) pylori. Specimens from 34 of the patients harbouredHelicobacter pylori along the mucosal surface and 13 of these featured, in addition, immunopositive material within the lamina propria. The remaining 18 biopsies were non-reactive. This observation suggests thatHelicobacter pylori can penetrate the epithelium and its basement membrane, resulting in the production of specific systemic antibodies.
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Andersen LP, Holck S, Elsborg L, Povlsen CO, Justesen T:Campylobacter pyloridis and peptic ulcer disease. I: histopathological findings. Scandinavian Journal of Gastroenterology 1987, 22: 219–224.
Andersen LP, Elsborg L, Justesen T:Campylobacter pylori in peptic ulcer diseases. II: Endoscopy and microbiological findings. Scandinavian Journal of Gastroenterology 1988, 23: 760–764.
Jones DM, Lessells AM, Eldridge J: Campylobacter-like organisms on the gastric mucosa: culture, histological and serological studies. Journal of Clinical Pathology 1984, 37: 1002–1006.
Marshall BJ, Warren JR: Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984, i: 1311–1315
Meyrick-Thomas J, Poynter D, Goading C, Woodings DF, Selway S, Cook AR, Hill MJ, Misiewicz JJ: Gastric spiral bacteria. Lancet 1984, ii: 100.
Price AB: Histological aspects ofCampylobacter pylori colonisation and infection of gastric and duodenal mucosa. Scandinavian Journal of Gastroenterology 1988, 23, Supplement 142: 22–24.
Rollason TP, Stone J, Rhodes JM: Spiral organisms in endoscopic biopsies of the human stomach. Journal of Clinical Pathology 1984, 37: 23–26.
Warren JR: Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983, i: 1273.
Aase S, Elgjo K, Fansa O, Bjørneklett A, Nederskov-Sørensen P, Bukholm G: Bacteria of the gastric antrum and their relation to chronic gastritis. Acta Pathologica, Microbiologica et Immunologica Scandinavica 1988, 96: 273–279.
Bode G, Malfertheiner P, Ditschuneit H: Pathogenic implications of ultrastructural findings inCampylobacter pylori related gastroduodenal diseases. Scandinavian Journal of Gastroenterology 1988, 23, Supplement 142: 25–39.
Buck GE, Gourley WK, Lee WK, Subramanjam K, Latimer JM, DiNuzzo AR: Relation ofCampylobacter pyloridis to gastric and peptic ulcer. Journal of Infectious Diseases 1986, 153: 664–669.
Kaldor J, Tee W, McCarthy P, Watson J, Duyer B: Immunoresponse toCampylobacter pyloridis in patients with peptic ulceration. Lancet 1985, i: 921.
Meiselman MS, Miller-Cathpole R, Christ M, Randall E:Campylobacter pylori gastritis in the acquired immunodeficiency syndrome. Gastroenterology 1988, 95, 209–212.
Andersen LP, Holck S, Povlsen CO:Campylobacter pyloris detected by an indirect immunohistochemical technique. Acta Pathologica, Microbiologica et Immunologica Scandinavia 1988, 96: 559–564.
Baume, JA (ed.): Handbook of immunperoxidase staining methods. Dako, Santa Barbara, CA, 1983.
Harbo M, Ingild A: Immunization, isolation of immunoglobulins, estimation of antibody titre. Scandinavian Journal of Immunology 1973, 2, Supplement 1: 161–164.
Bode G, Malfertheiner P, Lehnhardt G, Ströhle A, Ditschuneit H: Polymorphism ofCampylobacter pylori due to aging and Chemical Induction. Klinische Wochenschrift 1989, 67, Supplement 18: 4–5.
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Andersen, L.P., Holck, S. Possible evidence of invasiveness ofHelicobacter (Campylobacter)pylori . Eur. J. Clin. Microbiol. Infect. Dis. 9, 135–138 (1990). https://doi.org/10.1007/BF01963640
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DOI: https://doi.org/10.1007/BF01963640