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Antithyroid effect of a food or drug preservative: 4-hydroxybenzoic acid methyl ester

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Summary

4-hydroxybenzoic acid methyl ester (methylparaben) inhibits organification of iodide by isolated hog thyroid cells. The concentration which produces a 50% inhibition was about 2.0×10−4M. A similar inhibition was observed in nonstimulated and TSH- or dibutyryl cyclic AMP-stimulated cells. Neither iodide uptake nor cyclic AMP generation were altered by methylparaben.

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Authors and Affiliations

  1. Laboratoire de Médecine Expérimentale, Faculté de Médecine Alexis Carrel, FRA INSERM No. 30, rue Guillaume-Paradin, F-69008, Lyon, France

    B. Rousset

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  1. B. Rousset
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Rousset, B. Antithyroid effect of a food or drug preservative: 4-hydroxybenzoic acid methyl ester. Experientia 37, 177–178 (1981). https://doi.org/10.1007/BF01963218

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  • DOI: https://doi.org/10.1007/BF01963218

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