Skip to main content
SpringerLink
Log in

Effect of dimethindene, an antihistaminic drug, on the transmembrane potentials of mammalian myocardium

  • Short Communications
  • Pharmacology, Toxicology
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Dimethindene (DMI) decreased the maximum rate of rise of action potential (AP) without changing the resting potential in cat ventricular myocardium. DMI abolished the histamine-induced slow APs in left atria but not in right ventricular papillary muscles of guinea-pig, suggesting that DMI blocked the histamine H1-receptors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Barrett, W. E., Huebner, C. F., Rutledge, R. A., Dietrich, A., and Plummer, A. J., Toxic. appl. Pharmac.3 (1961) 534.

    Article  CAS  Google Scholar 

  2. Lorenz, W., Thermann, M., Hamelmann, H., Schmal, A., Maroske, D., Reimann, H. J., Kusche, J., Schingale, F., Dormann, P., and Keck, P., in: Symposium on histamine H2-receptors, p. 151. Eds. C. J. Wood and M. A. Simkins. Deltakos Ltd, London 1973.

    Google Scholar 

  3. Thermann, T., Lorenz, W., Schmal, A., Schingale, F., Dormann, P., and Hammelmann, H., Agents Actions7 (1977) 97.

    Article  CAS  PubMed  Google Scholar 

  4. Hlavacsek-Póka, E., Szentmiklósi, J., Cseppentö, Á., and Szegi, J., Orv. Hétil. (1982) in press.

  5. Kelemen, K., Kecskeméti, V., Scultéty, L., and Friedmann, T., Acta physiol. hung.33 (1968) 269.

    CAS  PubMed  Google Scholar 

  6. Mészáros, J., Kecskeméti, V., and Szegi, J., Eur. J. Pharmac.74 (1981) 181.

    Article  Google Scholar 

  7. Pappano, A. J., Circulation Res.27 (1970) 379.

    Article  CAS  PubMed  Google Scholar 

  8. Vaughan Williams, E. M., Pharmac. Ther.BI (1975) 115.

    Google Scholar 

  9. Szekeres, L., and Papp, Gy., in: Experimental cardiac arrhythmias and antiarrhythmic drugs, p. 287. Akadémiai Kiadó, Budapest 1971.

    Google Scholar 

  10. Hauswirth, O., and Singh, B. N., Pharmac. Rev.30 (1979) 5.

    Google Scholar 

  11. Hondeghem, L. M., and Katzung, B. G., Biochim. biophys. Acta472 (1977) 373.

    Article  CAS  PubMed  Google Scholar 

  12. Schneider, J. A., and Sperelakis, N., J. molec. Cell Cardiol.7 (1975) 249.

    Article  CAS  Google Scholar 

  13. Levi, R., Allan, G., and Zavecz, J. H., Fedn Proc.35 (1976) 1942.

    CAS  Google Scholar 

  14. Kesckeméti, V., Pol. J. Pharmac. Pharm.30 (1978) 377.

    Google Scholar 

  15. Josephson, I., Renaud, J. F., Vogel, S., McLean, M., and Sperelakis, N., Eur. J. Pharmac.35 (1976) 393.

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. E. Hlavacsek-Póka (Visiting scientist)

    Present address: Division of Pharmacology, Biogal Pharmaceutical Works, Debrecen, Hungary

Authors and Affiliations

  1. Department of Pharmacology, Medical University of Debrecen, H-4012, Debrecen, Hungary

    J. Mészáros, E. Hlavacsek-Póka (Visiting scientist) & J. Szegi

Authors
  1. J. Mészáros
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Hlavacsek-Póka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Szegi
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

To whom reprint requests should be addressed.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mészáros, J., Hlavacsek-Póka, E. & Szegi, J. Effect of dimethindene, an antihistaminic drug, on the transmembrane potentials of mammalian myocardium. Experientia 39, 400–402 (1983). https://doi.org/10.1007/BF01963146

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01963146

Keywords

Search

Navigation