Summary
Mice infected with Dengue virus show a depressed immune response to lipopolysaccharide (LPS), a helper T-cell-independent antigen, when LPS was administered on day 0, 6 and 12 post infection. Mice injected with inactivated virus failed to show immunosuppression.
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We are grateful to Dr P. K. Ramachandran, Defence Research and Development Establishment, Gwalior, Dr B. P. Saxena and Dr K. M. Rao for the encouragement and sustained interest. Thanks are also due to Mr A. Daniel for the help rendered in preparing the manuscript.
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Nagarkatti, M., Nagarkatti, P.S. Suppression of intrinsic B-cell function in Dengue-infected mice. Experientia 35, 1518–1519 (1979). https://doi.org/10.1007/BF01962820
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DOI: https://doi.org/10.1007/BF01962820