Abstract
The minimum dosage of antibiotics which reduced mortality in rats intraperitoneally inoculated with anEscherichia coli isolate was determined. Low mortality rates (0–10%) were obtained when antibiotics with minimal or no inoculum effect (cefoxitin, cefmetazole and gentamicin) were administered to yield serum levels 3 to 20 times the MIC, while antibiotics with a pronounced inoculum effect (cefotaxime and aztreonam) had to be administered to yield serum levels 200 to 1,000 times the MIC determined with a standard (low) inoculum. Thus, it seems that the inoculum effect observed in vitro with some antibiotics forEscherichia coli may have clinical significance.
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Soriano, F., Santamaría, M., Ponte, C. et al. In vivo significance of the inoculum effect of antibiotics onEscherichia coli . Eur. J. Clin. Microbiol. Infect. Dis. 7, 410–412 (1988). https://doi.org/10.1007/BF01962350
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DOI: https://doi.org/10.1007/BF01962350