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Bilateral breast cancer: one disease or two?

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Abstract

Our purpose was to determine whether bilateral breast cancer depends upon genetic predisposition to multiple tumors or, alternatively, represents two independent sporadic events. Biological concordance of hormone receptors and histopathology in bilateral tumors, family history of breast cancer, age at diagnosis, and survival were evaluated in 88 patients. The immunoreactivity of paired tumors from 51 patients to six different immunocytochemical markers was compared.

Neither histologic patterns nor immunocytochemical reactions showed concordance between bilateral tumors. Absence of concordance (other than for estrogen receptors) and lack of associations with positive family history and early age of onset support an interpretation of independent tumor origins and does not suggest a major role for genetic determinants in the majority of cases of bilateral breast cancer.

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References

  1. Lynch HT, Fain PR, Golgar D, et al.: Familial breast cancer and its recognition in an oncology clinic. Cancer 47: 2730–2739, 1981

    PubMed  Google Scholar 

  2. Schwartz AG, King MC, Belle SH, et al.: Risk of breast cancer to relatives of young breast cancer patients. J Nat Cancer Inst 75: 665–668, 1985

    PubMed  Google Scholar 

  3. Newman B, Austin MA, Lee M, King MC: Inheritance of human breast cancer: Evidence for autosomal dominant transmission in high-risk families. Proc Natl Acad Sci USA 85: 3044–3049, 1988

    PubMed  Google Scholar 

  4. Lynch HT, Watson P, Conway T, et al.: Breast cancer family history as a risk factor for early onset breast cancer. Breast Cancer Res Treat 11: 263–267, 1988

    Article  PubMed  Google Scholar 

  5. Kilgore AR: The incidence of cancer in the second breast. JAMA 77: 454–457, 1921

    Google Scholar 

  6. Robbins GF, Berg JW: Bilateral primary breast cancers: a prospective clinicopathological study. Cancer 12: 1501–1527, 1964

    Google Scholar 

  7. Prior P, Waterhouse JAH: Incidence of bilateral tumours in a population-based series of breast-cancer patients: I. Two approaches to an epidemiological analysis. Brit J Cancer 37: 620–634, 1978

    PubMed  Google Scholar 

  8. Chaudary MA, Millis RR, Hoskins EOL, et al.: Bilateral primary breast cancer: a prospective study of disease incidence. Brit J Surg 71: 711–714, 1984

    PubMed  Google Scholar 

  9. Schell SR, Montague ED, Spanos WJ Jr, et al.: Bilateral breast cancer in patients with initial Stage I and II disease. Cancer 50: 1191–1194, 1982

    PubMed  Google Scholar 

  10. Fisher ER, Fisher B, Sass R, Wickerham L: Pathologic findings from the National Surgical Adjuvant Breast Project (Protocol No. 4), XI. Bilateral breast cancer. Cancer 54: 3002–3011, 1984

    PubMed  Google Scholar 

  11. Mueller CB, Ames F: Bilateral carcinoma of the breast: Frequency and mortality. Canad J Surg 21: 459–465, 1978

    PubMed  Google Scholar 

  12. Hislop TG, Elwood JM, Coldman AJ, et al.: Second primary cancers of the breast: Incidence and risk factors. Brit J Cancer 49: 79–85, 1984

    PubMed  Google Scholar 

  13. Bailey MJ, Royce C, Sloane JP, et al.: Bilateral carcinoma of the breast. Brit J Surg 67: 514–516, 1980

    PubMed  Google Scholar 

  14. Burns PE, Dabbs K, May C, et al.: Bilateral breast cancer in northern Alberta: risk factors and survival patterns. Can Med Assoc J 130: 881–886, 1984

    PubMed  Google Scholar 

  15. Khafagy MM, Schottenfeld D, Robbins GF: Prognosis of the second breast cancer; the role of previous exposure to the first primary. Cancer 35: 596–599, 1975

    PubMed  Google Scholar 

  16. Berte E, Buzdar AK, Smith TL, Hortobagyi GN: Bilateral primary breast cancer in patients treated with adjuvant therapy. Am J Clin Oncol (CCT) 11: 114–118, 1988

    Google Scholar 

  17. Fracchia AA, Robinson D, Legaspi A, et al.: Survival in bilateral breast cancer. Cancer 55: 1414–1421, 1985

    PubMed  Google Scholar 

  18. Holdaway IM, Mason BH, Bennett RC, et al.: Estrogen receptors in bilateral breast cancer. Cancer 62: 109–113, 1988

    PubMed  Google Scholar 

  19. Lundy J, Mishriki Y, Varma AO, et al.: Tumor-associated antigens in bilateral breast cancer. J Surg Oncol 35: 24–29, 1987

    PubMed  Google Scholar 

  20. Bloom HJG, Richardson WW: Histological grading and prognosis in breast cancer. Brit J Cancer 11: 359–377, 1957

    PubMed  Google Scholar 

  21. Dawson PJ, Karrison T, Ferguson DJ: Histologic features associated with long-term survival in breast cancer. Human Pathol 17: 1015–1021, 1986

    Google Scholar 

  22. Singhakowinta A, Potter HG, Buroker TR, et al.: Estrogen receptor and natural course of breast cancer. Ann Surg 183: 84–88, 1976

    PubMed  Google Scholar 

  23. Nuti M, Teramoto YA, Mariano-Costantini R, et al.: A monoclonal antibody (B72.3) defines patterns of distribution of a novel tumor-associated antigen in human mammary carcinoma cell populations. Int J Cancer 29: 539–545, 1982

    PubMed  Google Scholar 

  24. Kufe D, Inghirami G, Abe M, et al.: Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma 3: 223–232, 1984

    PubMed  Google Scholar 

  25. Slamon DJ, Clark GM, Wong SG, et al.: Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177–182, 1987

    PubMed  Google Scholar 

  26. Kuhajda FP, Bohn H, Mendelsohn G: Pregnancy-specific beta-1 glycoprotein (SP-1) in breast carcinoma. Cancer 54: 1392–1396, 1984

    PubMed  Google Scholar 

  27. Yuan D, Hendler FJ, Vitetta ES: Characterization of a monoclonal antibody reactive with a subset of human breast tumors. J Nat Cancer Inst 68: 719–728, 1982

    PubMed  Google Scholar 

  28. Yuan D, Dawson PJ: Relationships between histology, monoclonal antibody reactivity, and prognosis in breast cancer. Hum Pathol 18: 1097–1100, 1987

    PubMed  Google Scholar 

  29. Mitchell KF: A carcinoembryonic antigen (CEA) specific monoclonal hybridoma antibody that reacts only with high-molecular-weight CEA. Cancer Immunol Immunother 10: 1–5, 1980

    Article  Google Scholar 

  30. Hsu S-M, Raine L, Fanger H: The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabelled antibody (PA) procedures. J Histochem Cytochem 29: 577–580, 1981

    PubMed  Google Scholar 

  31. Wolman SR, Feiner H, Schinella RA, et al.: A retrospective analysis of breast cancer based on outcome differences. Human Pathol 22: 475–481, 1991

    Article  Google Scholar 

  32. Fliess JL: Statistical Methods for Rates and Proportions, 2d ed. John Wiley and Sons, New York, NY. 1981

    Google Scholar 

  33. Mehta CR, Patel NR: A network algorithm for performing Fisher's Exact test in rxc contingency tables. J Amer Statist Assn 78: 427–434, 1983

    Google Scholar 

  34. Lawless JE: Statistical Models and Methods for Lifetime Data. John Wiley and Sons, New York, 1982

    Google Scholar 

  35. SAS Institute Inc. Release 6.03 Edition. SAS Institute, Inc., Cary NC, 1988

  36. Anderson DE, Badzioch MD: Bilaterality in familial breast cancer patients. Cancer 56: 2092–2098, 1985

    PubMed  Google Scholar 

  37. Harris RE, Lynch HT, Guirgis HA: Familial breast cancer: Risk to the contralateral breast. J Nat Cancer Inst 60: 955–960, 1978

    PubMed  Google Scholar 

  38. Cady B: Familial bilateral cancer of the breast. Ann Surg 172: 264–272, 1970

    PubMed  Google Scholar 

  39. Knudson AG, Strong LC, Anderson DE: Heredity and cancer in man. Prog Med Genet 9: 113–158, 1973

    PubMed  Google Scholar 

  40. Rosen PP, Lesser ML, Senie RT, Kinne DW: Epidemiology of breast carcinoma, III: Relationship of family history to tumor type. Cancer 50: 171–179, 1982

    PubMed  Google Scholar 

  41. Adami H-O, Hansen J, Jung B, Rimsten A: Characteristics of familial breast cancer in Sweden: Absence of relation to age and unilateral versus bilateral disease. Cancer 48: 1688–1695, 1981

    PubMed  Google Scholar 

  42. Fisher ER, Gregorio RM, Fisher B: The pathology of invasive breast cancer: a syllabus derived from the findings of the National Surgical Adjuvant Breast Project (Protocol #4). Cancer 36: 1–85, 1975

    PubMed  Google Scholar 

  43. Esteban JM, Battifora H: Tumor immunophenotype: comparison between primary neoplasm and its metastases. Mod Pathol 3: 192–197, 1990

    PubMed  Google Scholar 

  44. Van de Vijver MJ, Peterse JL, Mooi WJ, et al.: Neuprotein overexpression in breast cancer: Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer. New Engl J Med 319; 1239–1245, 1988

    PubMed  Google Scholar 

  45. Kiang DT, Kennedy BJ, Snover DC: Biological and histological characteristics of simultaneous bilateral breast cancer. Lancet ii: 1105–1108, 1980

    Article  Google Scholar 

  46. Hahnel R, Twaddle E: The relationship between estrogen receptors in primary and secondary breast carcinomas and in sequential primary breast carcinomas. Breast Cancer Res Treat 5: 155–163, 1985

    Article  PubMed  Google Scholar 

  47. Ownby HE, Frederick J, Russo J, et al.: Racial differences in breast cancer patients. J Nat Cancer Inst 75: 55–60, 1985

    PubMed  Google Scholar 

  48. Huseby RA, Ownby HE, Frederick J, et al.: Node-negative breast cancer treated by modified radical mastectomy without adjuvant therapies: Variables associated with disease recurrence and survivorship. J Clin Oncol 6: 83–88, 1988

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, University of Chicago, Chicago, IL

    Peter J. Dawson

  2. Department of Pathology and Laboratory Medicine, University of South Florida, Tampa, FL

    Peter J. Dawson

  3. Michigan Cancer Foundation, 110 E. Warren, Detroit, MI

    Terry Maloney, Phyllis Gimotty, Paul Juneau & Sandra R. Wolman

  4. Blood Services, American Red Cross, Southeastern Michigan Chapter, Detroit, MI

    Helen Ownby

  5. Department of Pathology, Wayne State University School of Medicine, Detroit, MI, USA

    Sandra R. Wolman

Authors
  1. Peter J. Dawson
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  2. Terry Maloney
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  3. Phyllis Gimotty
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  4. Paul Juneau
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  5. Helen Ownby
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  6. Sandra R. Wolman
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Dawson, P.J., Maloney, T., Gimotty, P. et al. Bilateral breast cancer: one disease or two?. Breast Cancer Res Tr 19, 233–244 (1991). https://doi.org/10.1007/BF01961160

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