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Interleukin 1 modulates collagen accumulation by rat granulation tissue cells both in vivo and in vitro

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In in vivo studies 0.5 U human interleukin 1 (IL-1) was incoculated daily into a subcutaneously implanted viscose cellulose sponge. IL-1 significantly decreased the dry weight (7.8%) and the hydroxyproline content (24.2%) of granulomas. When the cultured rat granulation tissue cells were exposed to IL-1 (0.5–2.0 U/ml) their collagen production decreased to 80% of that in controls. No effect on cell proliferation was detected.

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Authors and Affiliations

  1. Department of Medical Chemistry, University of Turku, Kiinamyllynkatu 10, SF-20520, Turku, Finland

    M. Laato & J. Heino

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  1. M. Laato
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  2. J. Heino
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Laato, M., Heino, J. Interleukin 1 modulates collagen accumulation by rat granulation tissue cells both in vivo and in vitro. Experientia 44, 32–34 (1988). https://doi.org/10.1007/BF01960234

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