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Inducement of blood vessel formation by ovarian extracts from mice injected with gonadotropins

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Summary

Ovarian extracts prepared from immature mice injected with human chorionic gonadotropin (hCG) and pregnant mare serum gonadotropin (PMSG) were assayed for angiogenic activity. The assay method consisted of implanting a film coated with ovarian extracts to the lateral wall of the m.rectus abdominus of a mouse for 20 days and examining the site for vascularization. The higher angiogenic activity obtained with PMSG-treated extract may be related to its follicle stimulating activity.

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Authors and Affiliations

  1. Department of Animal Science, College of Agriculture, Kyoto University, 606, Kyoto, Japan

    E. Sato, T. Ishibashi & S. S. Koide

  2. Center for Biomedical Research, The Population Council, 1230 York Avenue, 10021, New York, New York, USA

    E. Sato, T. Ishibashi & S. S. Koide

Authors
  1. E. Sato
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  2. T. Ishibashi
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  3. S. S. Koide
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Additional information

Acknowledgment. Part of this work was supported by a grant from The Ministry of Education, Japan (No. 576165).

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Sato, E., Ishibashi, T. & Koide, S.S. Inducement of blood vessel formation by ovarian extracts from mice injected with gonadotropins. Experientia 38, 1248–1249 (1982). https://doi.org/10.1007/BF01959768

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  • DOI: https://doi.org/10.1007/BF01959768

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