Abstract
Type I collagen is the major component of bone matrix; circulating carboxyterminal propeptide of type I procollagen (P-I-CP) levels reflect type I collagen synthesis in tissues and may be an useful index to investigate bone metabolism. We measured P-I-CP by a new radioimmunoassay in 300 healthy children and adolescents and in 40 healthy adults to provide reference data for P-I-CP values. In addition, 79 patients with diagnosed disorders of phospho-calcium metabolism (rickets, vitamin D deficient and vitamin D resistant, hyperparathyroidism, hypo- and pseudo-hypoparathyroidism, osteopenia) were evaluated. In the healthy subjects, serum P-I-CP values were higher in children than in adults; variations of P-I-CP levels were observed according to age and sexual maturation: higher values were found in the first years of life and during pubertal development; pubertal increase reflects the different timing of pubertal development in the two sexes. P-I-CP levels were increased in primary hyperparathyroidism and reduced in diseases related to impaired secretion or action of parathyroid hormone. Higher P-I-CP levels were found in vitamin D deficient and vitamin D resistant rickets. P-I-CP was reduced in anorexia nervosa and during chronic glucocorticoid treatment while it was increased in thyrotoxic osteoporosis. In idiopathic juvenile osteoporosis, P-I-CP values ranged from reduced to increased values. We conclude that P-I-CP may represent an additional biochemical marker of bone metabolism. Since age-related variations are present, reference data for the various ages are need for clinical application of this assay.
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Abbreviations
- IJO:
-
idiopathic juvenile osteoporosis
- P-I-CP:
-
carboxy-terminal prepeptide of type I procollagen
- PTH:
-
parathyroid hormone
- 25-OH-D:
-
25-hydroxyvitamin D
References
Ayers JWT, Gidwani GP, Schmidt IMV, Gross M (1984) Osteopenia in hypoestrogenic young women with anorexia nervosa. Fertil Steril 41:224–228
Azria M (1989) The value of biomarkers in detecting alterations in bone metabolism. Calcif Tissue Int 45:7–11
Burgeson RE (1988) New collagens, new concepts. Ann Rev Cell Biol 4:551–577
Castells S (1990) Osteoporosis. In: Castells S, Finnberg (eds) Metabolic bone disease in children. M. Dekker Inc, New York, pp 277–319
Cole DEC, Carpenter TO, Gundberg CM (1985) Serum osteocalcin concentrations in children with metabolic bone disease. J Pediatr 106:770–776
Colle M, Ruffie A (1989) L'osteocalcine chez l'enfant. Arch Fr Pediatr 46:315–317
Daneman D, Kooh SV, Fraser DR (1982) Hypoparathyroidism and pseudohypoparathyroidism in childhood. Clin Endocrinol Metab 1:211–227
Delemarre-van de Waal HA, Martens F, Odnik RJH (1991) Type I procollagen levels in relation to growth, growth hormone, SM-C and sex steroids throughout normal puberty (abstract) Horm Res 35(S2):41
Gilsanz V, Gibbens DT, Roe TF, Carlson M, Senac MO, Boechat MI, Huang HK, Schulz EE, Libanati CR, Cann CC (1988) Vertebral bone density in children: effect of puberty. Radiology 166:847–850
Glastre C, Braillon P, David L, Cochat P, Meunier PJ, Delmas PD (1990) Measurement of bone mineral content of the lumbar spine by dual energy x-ray absorptiometry in normal children: correlations with growth parameters. J Clin Endocrinol Metab 70:1330–1333
Greig F, Casas J, Castells S (1989) Changes in plasma osteocalcin concentrations during treatment of rickets. J Pediatr 114:820–823
Gundberg CM, Cole DEC, Lian LB, Reade TM, Gallop PM (1983) Serum osteocalcin in the treatment of inherited rickets with 1,25-dihydroxyvitamin D3. J Clin Endocrinol Metab 56:1063–1067
Kruse K, Kracht U (1986) Evaluation of serum osteocalcin as an index of altered bone metabolism. Eur J Pediatr 145:27–33
Lukert BP, Raisz LG (1990) Glucorticoid-induced osteoporosis: pathogenesis and management. Ann Intern Med 112:352–354
Melkko J, Niemi S, Risteli L, Risteli J (1990) Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen. Clin Chem 36:1328–1332
Parfitt AM, Simon LS, Villanueva AR, Krane SM (1987) Procollagen type I carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with iliac bone formation rates and comparison with total alkaline phosphatase. J Bone Mineral Res 2:427–436
Risteli J, Risteli L (1989) Growth and collagen. Curr Med Lit-Growth and Growth Factors 4:159–164
Saggese G, Federico G, Ghirri P, Cipriani J, Bertelloni S, Baroncelli GI (1986) Densitometria ossea in età pediatrica. Valori normali tra 2 e 19 anni. Primi dati italiani. Minerva Pediatr 38:545–551
Saggese G, Bertelloni S, Baroncelli GI (1990) Bone mineralization and calciotropic hormones in children with hyperthyroidism. Effects of methimazole therapy. J Endocrinol Invest 13:587–592
Schiele F, Henny J, Hitz J, Petitclere C, Guegen R, Siest G (1983) Total bone and liver alkaline phosphatase in plasma: Biological variations and reference limits. Clin Chem 29:634–639
Simon LS, Krane SM, Wortman PD, Krane IM, Kovitz KL (1984) Serum levels of type I and III procollagen fragments in Paget's disease of bone. J Clin Endocrinol Metab 58:110–120
Stamp TCB (1982) The clinical endocrinology of vitamin D. In: Parson AJ (ed) Endocrinology of calcium metabolism. Raven Press, New York, pp 363–422
Tanner JM, Whitehouse RH (1976) Clinical longitudinal standards for height, weight, height velocity, weight velocity and stages of puberty. Arch Dis Child 51:170–176
Trivedi P, Risteli J, Risteli L, Hindmarsh PC, Brook CGD, Mowat AP (1981) Serum concentrations of the type I and III procollagen propeptides as biochemical markers of growth velocity in healthy infants and children and in children with growth disorders. Pediatr Res 30:276–280
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Saggese, G., Bertelloni, S., Baroncelli, G.I. et al. Serum levels of carboxyterminal propeptide of type I procollagen in healthy children from 1 st year of life to adulthood and in metabolic bone diseases. Eur J Pediatr 151, 764–768 (1992). https://doi.org/10.1007/BF01959087
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DOI: https://doi.org/10.1007/BF01959087