Summary
The Maudsley Reactive and Non-Reactive strains have been developed as a model for the study of individual variations in stress-reactivity, and many differences in biobehavioral systems have been found between them. This review discusses limitations of the ‘emotionality’ construct in accounting for differences between the Maudsley strains and offers an alternative, theoretical approach. Amaral and Sinnamon have proposed that the locus ceruleus (LC) plays a stress-attenuating role in mediating behavioral, physiological and neuroendocrine response to prepotent, emergency-provoking stimuli and, building upon this formulation, it is proposed that the LC has been an important focus for gene action in the Maudsley model. It is suggested that the LC of the Non-Reactive strain is more strongly activated by stressful stimuli than the LC of Reactive rats, and is the basis of many of the behavioral and physiological differences between them. Behavioral and biochemical evidence consistent with this proposition is reviewed. Identification of the LC as a target for gene-action in the Maudsley model has an important advantage. It substitutes variations at a specific anatomic location in the brain for a loosely defined construct like emotionality, and the hypothesis is amenable to empirical tests by a variety of experimental approaches.
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References
Amaral, D. G., and Sinnamon, H. M., The locus coeruleus: neurobiology of a central noradrenergic nucleus. Progr. Neurobiol.9 (1977) 147–196.
Archer, J., Tests for emotionality in rats and mice—a review. Anim. Behav.21 (1973) 205–235.
Aston-Jones, G., and Bloom, F. E., Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli. J. Neurosci.1 (1981) 887–900.
Aston-Jones, G., Ennis, M., Pieribone, V. A., Nickell, W. T., and Shipley, M. T., The train nucleus locus coeruleus: restricted afferent control of a broad efferent network. Science234 (1986) 734–737.
Bailey, D. W., Sources of subline divergence and their relative importance for sublines of 6 major inbred strains of mice, in: Origins of Inbred Mice. Ed. H. C. Morse III. Academic Press, New York 1978.
Blizard, D. A., The Maudsley Reactive and Non-Reactive strains: A North American Perspective. Behav. Genet.11 (1981) 469–489.
Blizard, D. A., Altman, H. J., and Freedman, L. S., The peripheral sympathetic nervous system in rat strains selectively bred for differences in response to stress. Behav. Neural Biol.34 (1982) 319–325.
Blizard, D. A., Freedman, L. S., and Liang, B., Genetic variation, chronic stress, and the central and peripheral noradrenergic systems. Am. J. Physiol.245 (1983) R600-R605.
Blizard, D. A., Hansen, C. T., and Freedman, L. S., Open-field behavior and the peripheral sympathetic nervous system in the MR/N and MRN/N rat strains. Behav Gent.12 (1982) 459–466.
Blizard, D. A., and Liang, B., Plasma catecholamines under basal and stressful conditions in rat strains selectively bred for differences in response to stress, in: Catecholamines: Basic and Clinical Frontiers. Ed. E. Usdin. Pergamon Press, New York 1979.
Blizard, D. A., Liang, B., and Emmel, D. K., Blood-pressure, heartrate and plasma catecholamines under resting conditions in rat strains selectively bred for differences in response to stress. Behav. Neural Biol.29 (1980) 487–492.
Broadhurst, P. L., Emotionality and the Yerkes-Dodson law. J. exp. Psychol.54 (1957) 345–352.
Broadhurst, P. L., The interaction of task difficulty and motivation: the Yearkes-Dodson law revived. Acta psychol. Amst.16 (1959) 321–338.
Broadhurst, P. L., Experiments in psychogenetics: Applications of biometrical genetics to the inheritance of behavior, in: Experiments in Personality, vol. 1, Psychogenetics and Psychopharmacology. Ed. H. J. Eysenck. Routledge and Kegan Paul, London 1960.
Broadhurst, P. L., A note on further progress in a psychogenetic selection experiment. Psychol. Rep.10 (1962) 65–66.
Broadhurst, P. L., Summation of drives: a study of the combined effects of air and food deprivation, in: Experiments in Motivation. Ed. H. J. Eysenck. Pergamon Press, London 1964.
Broadhurst, P. L., The Maudsley Reactive and Non-Reactive strains of rats. Behav. Genet.5 (1975) 299–319.
Broadhurst, P. L., and Levine, S., Behavioral consistency in strains of rats selectively bred for emotional elimination. Br. J. Psychol.54 (1963) 121–125.
Brodal, A., Neurological anatomy in relation to clinical medicine, 2nd edn. Oxford University Press, New York 1964.
Descarries, L., and Lapierre, Y., Noradrenergic axon terminals in the cerebral cortex of rat. I. Radioautographic visualization after topical application of DL-(3H)-norepinephrine. Brain Res.51 (1973) 141–160.
Descarries, L., Watkins, K. C., and Lapierre, Y., Noradrenergic axon terminals in the cerebral cortex of rat. III Topometric ultrastructural analysis. Brain Res.133 (1977) 197–222.
Eysenck, H. J., and Broadhurst, P. L., Experiments with animals: Introduction, in: Experiments in Motivation, p. 285. Ed. H. J. Eysenck. Pergamon, Oxford 1964.
Freedman, R., Hoffer, B. J., Woodard, D. J., and Puro, D., Interaction of norepinephrine with cerebellar activity evoked by mossy and climbing fibers. Exp. Neurol.55 (1977) 269–288.
Hall, C. S., The genetics of behavior, in: Handbook of Experimental Psychology. Ed. S. S. Stevens. Wiley, New York 1951.
Harrington, G. M., The Har strains of rats: origins and characteristics. Behav. Genet.11 (1981) 445–468.
Harrington, G. M., and Blizard, D. A., Open-field behavior in the Maudsley Reactive and Non-Reactive strains: procedural variations. Behav. Genet.13 (1983) 91–94.
Hirsch, J., Behavior-Genetic Analysis. McGraw-Hill, New York 1967.
Hobson, J. A., and Brazier, M. A. B., The reticular formation revisited. Raven Press, New York 1979.
Kobayashi, R. M., Palkovits, M., Kopin, I. J., and Jacobowitz, D. M., Biochemical mapping of noradrenergic nerves arising from the rat locus ceruleus. Brain Res.77 (1974) 269–279.
Liang, B., and Blizard, D. A., Central and peripheral norepinephrine concentrations in rat strains selectively bred for differences in response to stress: confirmation and extension. Pharmac. Biochem. Behav.8 (1978) 75–80.
Liang, B., Dunlap, C. E., Freedman, L. S., and Blizard, D. A., Variation in number and affinity of cardiac beta-receptors in the Maudsley Reactive and Non-Reactive strains. Life Sci.31 (1982) 533–539.
Owen, S., The effect on avoidance response extinction in rats of CS continuation and emotional constitution. J. genet. Psychol.103 (1962) 147–151.
Reis, D. J., Joh, T. H., and Ross, R. A., Effects of reserpine on activities and amounts of tyrosine hydroxylase and dopamine-hydroxylase in catecholamine neuronal systems in rat brain. J. Pharmac. exp. Ther.193 (1975) 775–783.
Savage, R. D., and Eysenck, H. J., The definition and measurement of emotionality, in: Experiments in Motivation, p. 292–314. Ed. H. J. Eysenck. Pergamon Press, Oxford 1964.
Segal, M., and Bloom, F. E., The action of norepinephrine in the rat hippocampus. IV. The effects of locus ceruleus stimulation on evoked hippocampal unit activity. Brain Res.107 (1978) 513–525.
Singh, S. D., Conditioned emotional response in the rat. I. Constitutional determinants. J. comp. physiol. Psychol.52 (1959) 574–578.
Slater, J., Blizard, D. A., and Pohorecky, L. A., Central and peripheral norepinephrine metabolism in rat strains selectively bred for differences in response to stress. Pharmac. Biochem. Behav.6 (1977) 511–520.
Snyder, D. W., and Reis, D. J., Sudden death following bilateral lesions of nucleus locus coeruleus. Neurosci. Abstr.1 (1975) 425.
Stone, E. A., Freedman, L. S., and Morgano, L. E., Bram and adrenal tyrosine hydroxylase activity after chronic footshock stress. Pharmac. Biochem. Behav.9 (1978) 551–553.
Sudak, H. S., and Maas, J. W., Behavioral-neurochemical correlation in Reactive and Non-reactive rats. Science46 (1964) 418–420.
Thompson, W. R., The inheritance of behavior: behavioral differences in fifteen mouse strains. Can. J. Psychol.7 (1953) 145–155.
Weiss, J. M., Glazer, H. I., and Pohorecky, L. A., Coping behavior and neurochemical changes: an alternative explanation for the original “learned helplessness” experiments, in: Animal Models in Human Psychobiology. Eds G. Serban and A. Kling. Plenum Press, New York 1976.
Zigmond, R. E., Schon, F., and Iversen, L. L., Increased tyrosine hydroxylase activity in the locus coeruleus of the rat brain after reserpine treatment and cold stress. Brain Res.70 (1974) 547–552.
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Supported by MH-39210 from the National Institute of Mental Health to DAB
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Blizard, D.A. The locus ceruleus: a possible neural focus for genetic differences in emotionality. Experientia 44, 491–495 (1988). https://doi.org/10.1007/BF01958923
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DOI: https://doi.org/10.1007/BF01958923